Beta-carboline alkaloids derived from the ascidian Synoicum sp.

被引：41
|
作者：
Won, Tae Hyung [2 ]
Jeon, Ju-eun [2 ]
Lee, So-Hyoung [1 ]
Rho, Boon Jo [3 ]
Oh, Ki-Bong [1 ]
Shin, Jongheon [2 ]
机构：
[1] Seoul Natl Univ, Dept Agr Biotechnol, Coll Agr & Life Sci, Seoul 151921, South Korea
[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea
[3] Ehwa Womans Univ, Coll Life Sci, Dept Biol Sci, Seoul 120750, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 13期
基金：
新加坡国家研究基金会;
关键词：
beta-Carboline alkaloids; Eudistomin Y class; Synoicum sp; Chemical modification; Bioactivity; TUNICATE EUDISTOMA-OLIVACEUM; STAPHYLOCOCCUS-AUREUS; CELL-WALL; VIRULENCE; GLAUCUS; DERIVATIVES; INHIBITORS; SORTASE; GROWTH;
D O I：
10.1016/j.bmc.2012.05.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six beta-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y-1 (7) and six new derivatives, designated eudistomins Y-8-Y-13 (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na+/K+-ATPase. Structure-activity relationships were also deduced. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4082 / 4087
页数：6
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