A repeated-dose model of percutaneous drug absorption

被引：20

作者：

Kubota, K

Dey, F

Matar, SA

Twizell, EH ^{[1
]}

机构：

[1] Brunel Univ, Dept Math Sci, Uxbridge UB8 3PH, Middx, England

[2] Univ Tokyo, Fac Med, Dept Pharmacoepidemiol, Bunkyo Ku, Tokyo 1138655, Japan

来源：

APPLIED MATHEMATICAL MODELLING | 2002年 / 26卷 / 04期

关键词：

percutaneous absorption; repeated dose; partial differential equation; finite-difference method; bioavailability; pharmacokinetics; timolol;

D O I：

10.1016/S0307-904X(01)00068-3

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A mathematical model is developed for percutaneous absorption with regular applications of the drug. The linear partial differential equations (PDEs) of the model are solved using a finite-difference method which is second-order accurate in space and time. The solutions of these PDEs give the concentrations of the drug in the vehicle and the skin at a given time. The numerical results obtained are adapted to monitor the amount of drug released from the vehicle, the bio-availability for each application, the amount of drug in the skin at a given time, and the flux from the skin to the capillary at a given time. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：529 / 544

页数：16

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