A repeated-dose model of percutaneous drug absorption

被引：20
|
作者：
Kubota, K
Dey, F
Matar, SA
Twizell, EH [1 ]
机构：
[1] Brunel Univ, Dept Math Sci, Uxbridge UB8 3PH, Middx, England
[2] Univ Tokyo, Fac Med, Dept Pharmacoepidemiol, Bunkyo Ku, Tokyo 1138655, Japan
来源：
APPLIED MATHEMATICAL MODELLING | 2002年 / 26卷 / 04期
关键词：
percutaneous absorption; repeated dose; partial differential equation; finite-difference method; bioavailability; pharmacokinetics; timolol;
D O I：
10.1016/S0307-904X(01)00068-3
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A mathematical model is developed for percutaneous absorption with regular applications of the drug. The linear partial differential equations (PDEs) of the model are solved using a finite-difference method which is second-order accurate in space and time. The solutions of these PDEs give the concentrations of the drug in the vehicle and the skin at a given time. The numerical results obtained are adapted to monitor the amount of drug released from the vehicle, the bio-availability for each application, the amount of drug in the skin at a given time, and the flux from the skin to the capillary at a given time. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：529 / 544
页数：16
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