A repeated-dose model of percutaneous drug absorption

A mathematical model is developed for percutaneous absorption with regular applications of the drug. The linear partial differential equations (PDEs) of the model are solved using a finite-difference method which is second-order accurate in space and time. The solutions of these PDEs give the concentrations of the drug in the vehicle and the skin at a given time. The numerical results obtained are adapted to monitor the amount of drug released from the vehicle, the bio-availability for each application, the amount of drug in the skin at a given time, and the flux from the skin to the capillary at a given time. (C) 2002 Elsevier Science Inc. All rights reserved.