IL-33/ST2 axis in innate and acquired immunity to tumors

被引：58
|
作者：
Jovanovic, Ivan P. [1 ]
Pejnovic, Nada N. [1 ]
Radosavljevic, Gordana D. [1 ]
Arsenijevic, Nebojsa N. [1 ]
Lukic, Miodrag L. [1 ]
机构：
[1] Univ Kragujevac, Fac Med, Ctr Mol Med & Stem Cell Res, Kragulevac, Serbia
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 02期
关键词：
IL-33; ST2L; 4T1 mouse breast cancer; Th1/Th2; cells; cytotoxic response; NK cells; INFLAMMATION; TYPE-1;
D O I：
10.4161/onci.1.2.18131
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity.
引用
收藏
页码：229 / 231
页数：3
相关论文
共 50 条
  • [21] The role of the IL-33/ST2 axis in autoimmune disorders: Friend or foe?
    Liu, Xiuxing
    Xiao, Yichen
    Pan, Yuan
    Li, He
    Zheng, Song Guo
    Su, Wenru
    CYTOKINE & GROWTH FACTOR REVIEWS, 2019, 50 : 60 - 74
  • [22] The ST2/IL-33 Axis in immune Cells during inflammatory Diseases
    Griesenauer, Brad
    Paczesny, Sophie
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [23] IL-33/ST2 Axis: A Potential Therapeutic Target in Neurodegenerative Diseases
    Jia, Zexi
    Guo, Mengtian
    Ge, Xintong
    Chen, Fanglian
    Lei, Ping
    BIOMOLECULES, 2023, 13 (10)
  • [24] IL-33 is a crucial amplifier of innate rather than acquired immunity
    Oboki, Keisuke
    Ohno, Tatsukuni
    Kajiwara, Naoki
    Arae, Ken
    Morita, Hideaki
    Ishii, Akina
    Nambu, Aya
    Abe, Takaya
    Kiyonari, Hiroshi
    Matsumoto, Kenji
    Sudo, Katsuko
    Okumura, Ko
    Saito, Hirohisa
    Nakae, Susumu
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (43) : 18581 - 18586
  • [25] The mechanisms and significance of IL-33/ST2 in COPD
    Yuan, Zhi
    Zhang, Gensheng
    Chen, Zhiyong
    Liao, Kaixin
    Cheng, Zhong
    Li, Jingjie
    Feng, Malong
    Qun, Wang
    Chen, Zhihua
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (06): : 11193 - 11201
  • [26] The IL-33/ST2 Pathway in Cerebral Malaria
    Glineur, Corine
    Leleu, Ines
    Pied, Sylviane
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (21)
  • [27] IL-33/ST2 signaling in liver transplantation
    Tan, Zhongming
    Sun, Beicheng
    CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (03) : 761 - 763
  • [28] The Role of IL-33/ST2 Pathway in Tumorigenesis
    Larsen, Kristen M.
    Minaya, Maydelis Karla
    Vaish, Vivek
    Pena, Maria Marjorette O.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (09)
  • [29] MODULATION OF THE IL-33/ST2 AXIS FOR REGULATORY T CELL THERAPY IN TRANSPLANTATION
    Kawai, Kento
    Hester, Joanna
    Issa, Fadi
    TRANSPLANT INTERNATIONAL, 2019, 32 : 136 - 136
  • [30] IL-33/ST2 signaling in liver transplantation
    Zhongming Tan
    Beicheng Sun
    Cellular & Molecular Immunology, 2021, 18 : 761 - 763
12345