IL-33/ST2 axis in innate and acquired immunity to tumors

被引：58
|
作者：
Jovanovic, Ivan P. [1 ]
Pejnovic, Nada N. [1 ]
Radosavljevic, Gordana D. [1 ]
Arsenijevic, Nebojsa N. [1 ]
Lukic, Miodrag L. [1 ]
机构：
[1] Univ Kragujevac, Fac Med, Ctr Mol Med & Stem Cell Res, Kragulevac, Serbia
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 02期
关键词：
IL-33; ST2L; 4T1 mouse breast cancer; Th1/Th2; cells; cytotoxic response; NK cells; INFLAMMATION; TYPE-1;
D O I：
10.4161/onci.1.2.18131
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity.
引用
收藏
页码：229 / 231
页数：3
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