The role of the IL-33/ST2 axis in autoimmune disorders: Friend or foe?

被引：38
|
作者：
Liu, Xiuxing [1 ]
Xiao, Yichen [1 ]
Pan, Yuan [1 ]
Li, He [1 ]
Zheng, Song Guo [2 ]
Su, Wenru [1 ]
机构：
[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Guangdong, Peoples R China
[2] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2019年 / 50卷
基金：
国家重点研发计划;
关键词：
Interleukin-33; Autoimmune diseases; ST2; Th1; Th17; Type 2 immune responses; INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; NF-KAPPA-B; INFLAMMATORY-BOWEL-DISEASE; ANTIGEN-INDUCED ARTHRITIS; INCREASED SERUM-LEVELS; NECROSIS-FACTOR-ALPHA; INTERLEUKIN; 33; SOLUBLE ST2; MULTIPLE-SCLEROSIS;
D O I：
10.1016/j.cytogfr.2019.04.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Autoimmune diseases (ADs), which are common immune-mediated inflammatory syndromes, are characterized by an imbalance between T effector (Th)1/Th17 cells and T regulatory cells. Interleukin (IL)-33, a member of the IL-1 family, induces inflammatory disease development by mediating type 2 immune responses. Recently, IL-33/ST2 axis was reported to induce autoimmunity involving Th1 and Th17 cells. In this review, we focus on the expression, regulation and function of IL-33/ST2 pathway in the context of autoimmune disorders. We discuss the clinical potential of this signaling pathway in predicting disease activity and severity and offer possible future therapeutic alternatives.
引用
收藏
页码：60 / 74
页数：15
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