The IL-33/ST2 axis: Role in health and disease

被引：139
|
作者：
De la Fuente, Marjorie [1 ,2 ]
MacDonald, Thomas T. [3 ]
Hermoso, Marcela A. [1 ]
机构：
[1] Univ Chile, Fac Med, Inst Biomed Sci, Disciplinary Program Immunol, Santiago 8380453, CL, Chile
[2] Clin Las Condes, Dept Gastroenterol, Santiago, Chile
[3] Barts & London Queen Marys Sch Med & Dent, Blizard Inst, Ctr Immunol & Infect Dis, London, England
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 06期
关键词：
IL-33; ST2; Autoimmunity; Inflammatory bowel diseases; Table of contents; INFLAMMATORY-BOWEL-DISEASE; ALLERGIC AIRWAY INFLAMMATION; ST2; GENE-PRODUCT; ALTERNATIVELY ACTIVATED MACROPHAGES; RECEPTOR ACCESSORY PROTEIN; INNATE LYMPHOID-CELLS; CHRONIC HEART-FAILURE; SOLUBLE ST2; INTERLEUKIN-1; RECEPTOR; IL-1;
D O I：
10.1016/j.cytogfr.2015.07.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IL-33, an IL-1 family member, is expressed by many cell types and can regulate gene transcription. IL-33 is released upon cell necrosis and the precursor form is enzymatically processed, and then drives inflammation as a damage-associated molecular pattern. The IL-33 receptor ST2, encoded by IL1RL1, is expressed as both a membrane-anchored receptor (ST2L) activated by IL-33, and as a soluble variant (sST2) that exhibits anti-inflammatory properties. The IL-33/ST2 axis is involved in the pathogenesis of atopic and autoimmune diseases, cancer, and central nervous system disorders. Here, we review recent findings on the role of the IL-33/ST2 axis in health and disease. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：615 / 623
页数：9
相关论文
共 50 条
  • [1] Potential role of the IL-33/ST2 axis in celiac disease
    MA López-Casado
    P Lorite
    T Palomeque
    MI Torres
    Cellular & Molecular Immunology, 2017, 14 : 285 - 292
  • [2] IL-33/ST2 axis in autoimmune disease
    Shakerian, Leila
    Kolahdooz, Hanieh
    Garousi, Mitra
    Keyvani, Vahideh
    Kheder, Ramiar Kamal
    Faraj, Tola Abdulsattar
    Yazdanpanah, Esmaeil
    Esmaeili, Seyed-Alireza
    CYTOKINE, 2022, 158
  • [3] Potential role of the IL-33/ST2 axis in celiac disease
    Lopez-Casado, M. A.
    Lorite, P.
    Palomeque, T.
    Torres, M., I
    CELLULAR & MOLECULAR IMMUNOLOGY, 2017, 14 (03) : 285 - 292
  • [4] The role of IL-33/ST2 axis in Colorectal Cancer
    Mahmoud, A. M.
    O'Donnell, C. O. D.
    Carey, S. C.
    O'Riordain, M.
    Bennett, M. W. B.
    Brint, E. B.
    Houston, A. H.
    JOURNAL OF PATHOLOGY, 2015, 237 : S43 - S43
  • [5] Role of IL-33/ST2 axis in systemic inflammation of allergic airway disease
    Vocca, Lavinia
    Sala, Angelo
    Gangemi, Sebastiano
    Di Sano, Catarina
    Riccobono, Loredana
    Uasuf, Caren
    Anzalone, Giulia
    Bonanno, Anna
    Gagliardo, Rosalie Paola
    Profita, Mirella
    EUROPEAN RESPIRATORY JOURNAL, 2014, 44
  • [6] The Il-33/st2 Axis Is Upregulated In Fibrotic Lung Disease
    Toshner, R. J.
    Allden, S. J.
    Byrne, A. J.
    Lloyd, C. M.
    Maher, T. M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [7] IL-33/ST2 Axis in Organ Fibrosis
    Kotsiou, Ourania S.
    Gourgoulianis, Konstantinos I.
    Zarogiannis, Sotirios G.
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [8] IL-33/ST2 axis in inflammation and immunopathology
    Marija Milovanovic
    Vladislav Volarevic
    Gordana Radosavljevic
    Ivan Jovanovic
    Nada Pejnovic
    Nebojsa Arsenijevic
    Miodrag L. Lukic
    Immunologic Research, 2012, 52 : 89 - 99
  • [9] IL-33/ST2 axis in inflammation and immunopathology
    Milovanovic, Marija
    Volarevic, Vladislav
    Radosavljevic, Gordana
    Jovanovic, Ivan
    Pejnovic, Nada
    Arsenijevic, Nebojsa
    Lukic, Miodrag L.
    IMMUNOLOGIC RESEARCH, 2012, 52 (1-2) : 89 - 99
  • [10] The IL-33/ST2 Axis Is Not Required for the Profibrotic Effect of IL-33 in the Lungs
    Atamas, Sergei P.
    Lockatell, Virginia
    Todd, Nevins W.
    Luzina, Irina G.
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2024, 71 (04) : 499 - 501
12345