The IL-33/ST2 axis: Role in health and disease

被引：139

作者：

De la Fuente, Marjorie ^{[1
,2
]}

MacDonald, Thomas T. ^{[3
]}

Hermoso, Marcela A. ^{[1
]}

机构：

[1] Univ Chile, Fac Med, Inst Biomed Sci, Disciplinary Program Immunol, Santiago 8380453, CL, Chile

[2] Clin Las Condes, Dept Gastroenterol, Santiago, Chile

[3] Barts & London Queen Marys Sch Med & Dent, Blizard Inst, Ctr Immunol & Infect Dis, London, England

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 06期

关键词：

IL-33; ST2; Autoimmunity; Inflammatory bowel diseases; Table of contents; INFLAMMATORY-BOWEL-DISEASE; ALLERGIC AIRWAY INFLAMMATION; ST2; GENE-PRODUCT; ALTERNATIVELY ACTIVATED MACROPHAGES; RECEPTOR ACCESSORY PROTEIN; INNATE LYMPHOID-CELLS; CHRONIC HEART-FAILURE; SOLUBLE ST2; INTERLEUKIN-1; RECEPTOR; IL-1;

D O I：

10.1016/j.cytogfr.2015.07.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-33, an IL-1 family member, is expressed by many cell types and can regulate gene transcription. IL-33 is released upon cell necrosis and the precursor form is enzymatically processed, and then drives inflammation as a damage-associated molecular pattern. The IL-33 receptor ST2, encoded by IL1RL1, is expressed as both a membrane-anchored receptor (ST2L) activated by IL-33, and as a soluble variant (sST2) that exhibits anti-inflammatory properties. The IL-33/ST2 axis is involved in the pathogenesis of atopic and autoimmune diseases, cancer, and central nervous system disorders. Here, we review recent findings on the role of the IL-33/ST2 axis in health and disease. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：615 / 623

页数：9

共 50 条

[31] The IL-33/ST2 axis: yet another therapeutic target in inflammatory bowel disease?
Salas, Azucena
GUT, 2013, 62 (10) : 1392 - 1393
[32] Strategies targeting IL-33/ST2 axis in the treatment of allergic diseases
Li, Wenran
Liu, Mengqi
Chu, Ming
BIOCHEMICAL PHARMACOLOGY, 2023, 218
[33] Potential involvement of the IL-33/ST2 axis in the pathogenesis of Tatosubo Syndrome
Awada, Ahmad
Unger, Philippe
ACTA CARDIOLOGICA, 2019, 74 : 10 - 10
[34] Association of Common Variants in the IL-33/ST2 Axis with Ischemic Stroke
Li, Shuo
Wang, Zhijie
Liu, Xinjing
Li, Yuanzhe
Shi, Changhe
Wu, Jun
Sun, Shilei
Li, Yusheng
Li, Shaohua
Xu, Yuming
Song, Bo
CURRENT NEUROVASCULAR RESEARCH, 2019, 16 (05) : 494 - 501
[35] THE ROLE OF IL33 AND THE IL-33 RECEPTOR ST2 IN NEPHROTOXIC SERUM NEPHRITIS
Artinger, Katharina
Kirsch, Alexander H.
Aringer, Ida
Schabhuettl, Corinna
Krainer, Michaela
Eller, Philipp
Rosenkranz, Alexander R.
Eller, Kathrin
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2016, 31 : 372 - 372
[36] The ST2/IL-33 Axis in immune Cells during inflammatory Diseases
Griesenauer, Brad
Paczesny, Sophie
FRONTIERS IN IMMUNOLOGY, 2017, 8
[37] IL-33/ST2 Axis: A Potential Therapeutic Target in Neurodegenerative Diseases
Jia, Zexi
Guo, Mengtian
Ge, Xintong
Chen, Fanglian
Lei, Ping
BIOMOLECULES, 2023, 13 (10)
[38] Endogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma
Magat, Jenna M.
Thomas, Joanna L.
Dumouchel, Justin P.
Murray, Fiona
Li, Willis X.
Li, Jinghong
JOURNAL OF IMMUNOLOGY, 2020, 204 (06): : 1592 - 1597
[39] Stopping Inflammation in Stroke: Role of ST2/IL-33 Signaling
Drieu, Antoine
de Lizarrondo, Sara Martinez
Rubio, Marina
JOURNAL OF NEUROSCIENCE, 2017, 37 (40): : 9614 - 9616
[40] The potential role of IL-33/ST2 signaling in fibrotic diseases
Gao, Qiaoyan
Li, Yan
Li, Mingcai
JOURNAL OF LEUKOCYTE BIOLOGY, 2015, 98 (01) : 15 - 22

← 1 2 3 4 5 →