RETRACTED: Regenerating new heart with stem cells (Retracted Article)

被引:117
|
作者
Anversa, Piero [1 ]
Kajstura, Jan
Rota, Marcello
Leri, Annarosa
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, Boston, MA 02115 USA
来源
JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 01期
关键词
BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; CARDIAC PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; MONONUCLEAR-CELLS; MULTIPOTENT; PROLIFERATION; FAILURE; REPAIR; ACTIVATION;
D O I
10.1172/JCI63068
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This article discusses current understanding of myocardial biology, emphasizing the regeneration potential of the adult human heart and the mechanisms involved. In the last decade, a novel conceptual view has emerged. The heart is no longer considered a post:mitotic organ, but is viewed as a self-renewing organ characterized by a resident stem cell compartment responsible for tissue homeostasis and cardiac repair following injury. Additionally, HSCs possess the ability to transdifferentiate and acquire the cardiomyocyte, vascular endothelial, and smooth muscle cell lineages. Both cardiac and hematopoietic stem cells may be used therapeutically in an attempt to reverse the devastating consequences of chronic heart failure of ischemic and nonischemic origin.
引用
收藏
页码:62 / 70
页数:9
相关论文
共 50 条
  • [41] RETRACTED: Cell Adhesion and Spreading Affect Adipogenesis from Embryonic Stem Cells: The Role of Calreticulin (Retracted Article)
    Szabo, Eva
    Feng, Tianshu
    Dziak, Ewa
    Opas, Michal
    STEM CELLS, 2009, 27 (09) : 2092 - 2102
  • [43] RETRACTED: Recent Advances on Retinal Regeneration using Stem Cell (Retracted Article)
    Kim, Soon Hee
    Kim, Cho Min
    Hong, Hee Kyung
    Jo, Eun Hye
    Lee, Seon Kyoung
    Kim, Soo Jin
    Song, Yi-Seul
    Kim, Yun Tae
    Ahn, Sik Il
    Kang, Young Sun
    Joo, Choun-Ki
    Lee, Dongwon
    Rhee, John M.
    Khang, Gilson
    TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2009, 6 (4-11) : 762 - 791
  • [44] RETRACTED: Impacts of Angelica Polysaccharide on Proliferation and Differentiation of Mesenchymal Stem Cells of Rat Bone Marrow (Retracted Article)
    Yang, Shimao
    Gao, Fei
    Li, Min
    Gao, Zhennan
    JOURNAL OF HEALTHCARE ENGINEERING, 2022, 2022
  • [45] RETRACTED: Overexpression of NTRK1 Promotes Differentiation of Neural Stem Cells into Cholinergic Neurons (Retracted Article)
    Wang, Limin
    He, Feng
    Zhong, Zhuoyuan
    Lv, Ruiyan
    Xiao, Songhua
    Liu, Zhonglin
    BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [46] RETRACTED: Shengmai (a traditional Chinese herbal medicine) for heart failure (Retracted Article)
    Chen, Jie
    Yao, Yu
    Chen, Haining
    Kwong, Joey S. W.
    Chen, Jin
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (11):
  • [47] RETRACTED: Shengmai (a traditional Chinese herbal medicine) for heart failure (Retracted Article)
    Zheng, Huixian
    Chen, Yanling
    Chen, Jin
    Kwong, Joey
    Xiong, Wenmei
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2011, (02):
  • [48] RETRACTED: Shengmai (a traditional Chinese herbal medicine) for heart failure (Retracted Article)
    Zhou, Qin
    Qin, Wen-Zhe
    Liu, Shuai-Bin
    Kwong, Joey S. W.
    Zhou, Jing
    Chen, Jin
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2014, (04):
  • [49] RETRACTED: Effects of Amiodarone and Esmolol for Heart Rate and Cardiovascular Changes (Retracted Article)
    Wang, Hao
    Lei, Fengping
    Bai, Lei
    Zhang, Anping
    EMERGENCY MEDICINE INTERNATIONAL, 2022, 2022
  • [50] RETRACTED: Identification of a coronary vascular progenitor cell in the human heart (Retracted Article)
    Bearzi, Claudia
    Leri, Annarosa
    Lo Monaco, Francesco
    Rota, Marcello
    Gonzalez, Arantxa
    Hosoda, Toru
    Pepe, Martino
    Qanud, Khaled
    Ojaimi, Caroline
    Bardelli, Silvana
    D'Amario, Domenico
    D'Alessandro, David A.
    Michler, Robert E.
    Dimmeler, Stefanie
    Zeiher, Andreas M.
    Urbanek, Konrad
    Hintze, Thomas H.
    Kajstura, Jan
    Anversa, Piero
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (37) : 15885 - 15890