RETRACTED: Regenerating new heart with stem cells (Retracted Article)

被引:117
|
作者
Anversa, Piero [1 ]
Kajstura, Jan
Rota, Marcello
Leri, Annarosa
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, Boston, MA 02115 USA
来源
JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 01期
关键词
BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; CARDIAC PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; MONONUCLEAR-CELLS; MULTIPOTENT; PROLIFERATION; FAILURE; REPAIR; ACTIVATION;
D O I
10.1172/JCI63068
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This article discusses current understanding of myocardial biology, emphasizing the regeneration potential of the adult human heart and the mechanisms involved. In the last decade, a novel conceptual view has emerged. The heart is no longer considered a post:mitotic organ, but is viewed as a self-renewing organ characterized by a resident stem cell compartment responsible for tissue homeostasis and cardiac repair following injury. Additionally, HSCs possess the ability to transdifferentiate and acquire the cardiomyocyte, vascular endothelial, and smooth muscle cell lineages. Both cardiac and hematopoietic stem cells may be used therapeutically in an attempt to reverse the devastating consequences of chronic heart failure of ischemic and nonischemic origin.
引用
收藏
页码:62 / 70
页数:9
相关论文
共 50 条
  • [31] RETRACTED: Reproducibility (Retracted Article)
    Boylan, John E.
    IMA JOURNAL OF MANAGEMENT MATHEMATICS, 2016, 27 (02) : 107 - 108
  • [32] RETRACTED: Shared Genetic and Epigenetic Mechanisms between the Osteogenic Differentiation of Dental Pulp Stem Cells and Bone Marrow Stem Cells (Retracted Article)
    Gaus, Sebastian
    Li, Hanluo
    Li, Simin
    Wang, Qian
    Kottek, Tina
    Hahnel, Sebastian
    Liu, Xiangqiong
    Deng, Yupei
    Ziebolz, Dirk
    Haak, Rainer
    Schmalz, Gerhard
    Liu, Lei
    Savkovic, Vuk
    Lethaus, Bernd
    BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [33] RETRACTED: Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences (Retracted Article)
    Wislet-Gendebien, Sabine
    Laudet, Emerence
    Neirinckx, Virginie
    Alix, Philippe
    Leprince, Pierre
    Glejzer, Aneta
    Poulet, Christophe
    Hennuy, Benoit
    Sommer, Lukas
    Shakhova, Olga
    Rogister, Bernard
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2012, 69 (15) : 2593 - 2608
  • [34] RETRACTED ARTICLE: Differentiation of Mesenchymal Stem Cells into Neural Stem Cells Using Cerebrospinal Fluid
    Wei Ge
    Chao Ren
    Xin Duan
    Deqin Geng
    Caiyi Zhang
    Xiaoyun Liu
    Hao Chen
    Meirong Wan
    Runlu Geng
    Cell Biochemistry and Biophysics, 2015, 71 : 449 - 455
  • [35] RETRACTED: Development of human embryonic stem cell-derived hepatic cells for toxicology analysis (Retracted Article)
    Czysz, Kat
    Minger, Stephen
    Thomas, Nick
    Dohertyl, Pat
    TOXICOLOGY, 2011, 290 (2-3) : 113 - 114
  • [36] RETRACTED ARTICLE: Effect of apoptosis in neural stem cells treated with sevoflurane
    Jianlei Qiu
    Pengcai Shi
    Wude Mao
    Yuyi Zhao
    Wenshuai Liu
    Yuelan Wang
    BMC Anesthesiology, 15
  • [37] RETRACTED: Scanning Probe Microscopy Bone Marrow Determination of Steogenic Differentiation of Mesenchymal Stem Cells (Retracted Article)
    Fu, Xiandong
    Lian, Qixin
    Zhang, Bo
    Teng, Xinli
    Chen, Ying
    Qu, Yikun
    Cheng, Zhuoxin
    Guo, Linqi
    CONTRAST MEDIA & MOLECULAR IMAGING, 2022, 2022
  • [38] RETRACTED: Mesenchymal Stem/Stromal Cells as a Vehicle for Cytokine Delivery: An Emerging Approach for Tumor Immunotherapy (Retracted Article)
    Razeghian, Ehsan
    Margiana, Ria
    Chupradit, Supat
    Bokov, Dmitry O.
    Abdelbasset, Walid Kamal
    Marofi, Faroogh
    Shariatzadeh, Siavash
    Tosan, Foad
    Jarahian, Mostafa
    FRONTIERS IN MEDICINE, 2021, 8
  • [39] RETRACTED: Efficacy of Human Adipose Derived Mesenchymal Stem Cells in Promoting Skin Wound Healing (Retracted Article)
    Zhou, Lingcong
    Wang, Hui
    Yao, Sidi
    Li, Li
    Kuang, Xin
    JOURNAL OF HEALTHCARE ENGINEERING, 2022, 2022
  • [40] RETRACTED: Role of mesenchymal stem cells versus angiotensin converting enzyme inhibitor in kidney repair (Retracted Article)
    Ahmed, Hanaa H.
    Toson, Elshahat A.
    El-mezayen, Hatem A.
    Rashed, Laila A.
    Elsherbiny, Eslam S.
    NEPHROLOGY, 2017, 22 (07) : 531 - 540