RETRACTED: Regenerating new heart with stem cells (Retracted Article)

被引:117
|
作者
Anversa, Piero [1 ]
Kajstura, Jan
Rota, Marcello
Leri, Annarosa
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, Boston, MA 02115 USA
来源
JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 01期
关键词
BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; CARDIAC PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; MONONUCLEAR-CELLS; MULTIPOTENT; PROLIFERATION; FAILURE; REPAIR; ACTIVATION;
D O I
10.1172/JCI63068
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This article discusses current understanding of myocardial biology, emphasizing the regeneration potential of the adult human heart and the mechanisms involved. In the last decade, a novel conceptual view has emerged. The heart is no longer considered a post:mitotic organ, but is viewed as a self-renewing organ characterized by a resident stem cell compartment responsible for tissue homeostasis and cardiac repair following injury. Additionally, HSCs possess the ability to transdifferentiate and acquire the cardiomyocyte, vascular endothelial, and smooth muscle cell lineages. Both cardiac and hematopoietic stem cells may be used therapeutically in an attempt to reverse the devastating consequences of chronic heart failure of ischemic and nonischemic origin.
引用
收藏
页码:62 / 70
页数:9
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