RETRACTED: Regenerating new heart with stem cells (Retracted Article)

被引:117
|
作者
Anversa, Piero [1 ]
Kajstura, Jan
Rota, Marcello
Leri, Annarosa
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, Boston, MA 02115 USA
来源
JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 01期
关键词
BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; CARDIAC PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; MONONUCLEAR-CELLS; MULTIPOTENT; PROLIFERATION; FAILURE; REPAIR; ACTIVATION;
D O I
10.1172/JCI63068
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This article discusses current understanding of myocardial biology, emphasizing the regeneration potential of the adult human heart and the mechanisms involved. In the last decade, a novel conceptual view has emerged. The heart is no longer considered a post:mitotic organ, but is viewed as a self-renewing organ characterized by a resident stem cell compartment responsible for tissue homeostasis and cardiac repair following injury. Additionally, HSCs possess the ability to transdifferentiate and acquire the cardiomyocyte, vascular endothelial, and smooth muscle cell lineages. Both cardiac and hematopoietic stem cells may be used therapeutically in an attempt to reverse the devastating consequences of chronic heart failure of ischemic and nonischemic origin.
引用
收藏
页码:62 / 70
页数:9
相关论文
共 50 条
  • [1] RETRACTED: Evidence for Human Lung Stem Cells (Retracted Article)
    Kajstura, Jan
    Rota, Marcello
    Hall, Sean R.
    Hosoda, Toru
    D'Amario, Domenico
    Sanada, Fumihiro
    Zheng, Hanqiao
    Ogorek, Barbara
    Rondon-Clavo, Carlos
    Ferreira-Martins, Joao
    Matsuda, Alex
    Arranto, Christian
    Goichberg, Polina
    Giordano, Giovanna
    Haley, Kathleen J.
    Bardelli, Silvana
    Rayatzadeh, Hussein
    Liu, Xiaoli
    Quaini, Federico
    Liao, Ronglih
    Leri, Annarosa
    Perrella, Mark A.
    Loscalzo, Joseph
    Anversa, Piero
    NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (19): : 1795 - 1806
  • [2] RETRACTED: Diuretics for heart failure (Retracted Article)
    Faris, Rajaa F.
    Flather, Marcus
    Purcell, Henry
    Poole-Wilson, Philip A.
    Coats, Andrew J. S.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (02):
  • [3] RETRACTED: Differentiation of Mesenchymal Stem Cells into Neural Stem Cells Using Cerebrospinal Fluid (Retracted Article)
    Ge, Wei
    Ren, Chao
    Duan, Xin
    Geng, Deqin
    Zhang, Caiyi
    Liu, Xiaoyun
    Chen, Hao
    Wan, Meirong
    Geng, Runlu
    CELL BIOCHEMISTRY AND BIOPHYSICS, 2015, 71 (01) : 449 - 455
  • [4] RETRACTED: Safety Is the Heart of the Matter (Retracted Article)
    Campbell, Belinda A.
    Seymour, John F.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2020, 106 (03): : 462 - +
  • [5] RETRACTED: Effect of apoptosis in neural stem cells treated with sevoflurane (Retracted Article)
    Qiu, Jianlei
    Shi, Pengcai
    Mao, Wude
    Zhao, Yuyi
    Liu, Wenshuai
    Wang, Yuelan
    BMC ANESTHESIOLOGY, 2015, 15
  • [6] RETRACTED: Professional Competences in STEM Education (Retracted Article)
    Sabirova, Fairuza
    Vinogradova, Marina
    Isaeva, Anastasia
    Litvinova, Tatiana
    Kudinov, Sergey
    INTERNATIONAL JOURNAL OF EMERGING TECHNOLOGIES IN LEARNING, 2020, 15 (14) : 179 - 193
  • [7] RETRACTED: Online Technologies in STEM Education (Retracted Article)
    Liu, Zi-Yu
    Chubarkova, Elena
    Kharakhordina, Marina
    INTERNATIONAL JOURNAL OF EMERGING TECHNOLOGIES IN LEARNING, 2020, 15 (15) : 20 - 32
  • [8] RETRACTED: NKT Cells in Sepsis (Retracted Article)
    Leung, Briana
    Harris, Hobart W.
    CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2010,
  • [9] RETRACTED: Efficient derivation of new human embryonic stem cell lines (Retracted Article)
    Kim, SJ
    Lee, JE
    Park, JH
    Lee, JB
    Kim, JM
    Yoon, BS
    Song, JM
    Roh, SI
    Kim, CG
    Yoon, HS
    MOLECULES AND CELLS, 2005, 19 (01) : 46 - 53
  • [10] RETRACTED: For the origin of new geometry (Retracted Article)
    Kalimuthu, S.
    APPLIED MATHEMATICS LETTERS, 2010, 23 (12) : 1451 - 1453