Culcitiolides A-D, Four New Eremophilane-Type Sesquiterpene Derivatives from Senecio culcitioides

被引：0

作者：

Nozaki, Hiroshi ^{[1
]}

Hayashi, Ken-ichiro ^{[1
]}

Kawai, Mikiko ^{[2
]}

Mitsui, Taichi ^{[1
]}

Kido, Masahiro ^{[2
]}

Tani, Hiroyuki ^{[2
]}

Takaoka, Daisuke ^{[3
]}

Uno, Hidemitsu ^{[2
]}

Ohira, Susumu ^{[1
]}

Kuboki, Atsuto ^{[1
]}

Matsuura, Nobuyasu ^{[1
]}

机构：

[1] Okayama Univ Sci, Fac Sci, Dept Biol Chem, Okayama 7000005, Japan

[2] Ehime Univ, Grad Sch Sci & Engn, Matsuyama, Ehime 7908577, Japan

[3] Ehime Univ, Fac Gen Educ, Dept Chem, Matsuyama, Ehime 7908577, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 04期

关键词：

Senecio culcitioides; Eremophilane; Culcitiolide A-D; Nuclear factor kappa B; NF-KAPPA-B; MEDICINAL-PLANTS; PROTEINS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new eremophilane-type sesquiterpenes, culcitiolides A-D, were isolated from the stem of Senecio culcitioides Sch. Bip (Asteraceae). Their structures were established by detailed 2D NMR spectroscopic and single-crystal X-ray experiments. These compounds were assessed for inhibitory activity against nuclear factor kappa B (NF-kappa B). Culcitiolides C and D at 20 mu M showed 97 and 100% inhibition of NF-kappa B activity, respectively.

引用

页码：427 / 430

页数：4

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