Five new eremophilane-type sesquiterpenes from the fresh roots of Rehmannia glutinosa

被引：1
|
作者：
Li, Xiang-Da [1 ,2 ]
Cao, Yan-Gang [1 ,2 ]
Zhang, Yu-Han [1 ,2 ]
Ren, Ying-Jie [1 ,2 ]
Zeng, Meng-Nan [1 ,2 ]
Liu, Yan-Ling [1 ,2 ]
Chen, Xu [1 ,2 ]
Ma, Xin-Yi [1 ,2 ]
Zhao, Bing-Xian [1 ,2 ]
Zheng, Xiao-Ke [1 ,2 ,3 ]
Feng, Wei-Sheng [1 ,2 ,3 ]
机构：
[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China
[2] Engn & Technol Ctr Chinese Med Dev Henan Prov, Zhengzhou 450046, Peoples R China
[3] Collaborat Innovat Ctr Chinese Med & Resp Dis Coco, Zhengzhou 450046, Peoples R China
来源：
FITOTERAPIA | 2024年 / 175卷
关键词：
Scrophulariaceae; Rehmannia glutinosa; Sesquiterpenes; Anti-pulmonary fibrosis; IRIDOIDS; GLUCOSIDES;
D O I：
10.1016/j.fitote.2024.105960
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five undescribed eremophilane-type sesquiterpenes, remophilanetriols E -I ( 1 - 5 ), along with seven known compounds ( 6 - 12 ) were isolated from the fresh roots of Rehmannia glutinosa . Their structures were characterized by extensive spectroscopic data analysis and their absolute configurations were determined by comparing their calculated electronic circular dichroism (ECD) spectra and experimental ECD spectra. The anti-pulmonary fibrosis activities of all compounds were evaluated in vitro by MTT methods, and compounds 2 , 8 , 10 , and 12 exhibited excellent anti-pulmonary fibrosis activities. In addition, compound 2 can reduce the levels of ROS and apoptosis in TGF- beta 1-induced BEAS-2B cells.
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页数：7
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