Design, synthesis of some 2,6,9-trisubstituted purinyl thioureido derivatives and evaluation of antimicrobial activity

被引：11
|
作者：
Modi, Jigisha A. [1 ]
Patel, K. C. [1 ]
机构：
[1] VNSG Univ, Dept Chem, Surat 395007, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 08期
关键词：
Purine; Thioureido linkage; Minimum inhibitory concentration (MIC); INHIBITORS; POTENT;
D O I：
10.1007/s00044-011-9682-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some new trisubstituted purinyl thioureido were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains and antifungal strain using a micro dilution procedure. Synthesized compounds 6a-j prove to be effective with minimum inhibitory concentration (MIC) (mg ml(-1)), among them 6a, 6d, and 6e showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, H-1-NMR, and elemental analysis.
引用
收藏
页码：1660 / 1664
页数：5
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