Design, synthesis of some 2,6,9-trisubstituted purinyl thioureido derivatives and evaluation of antimicrobial activity

被引：11

作者：

Modi, Jigisha A. ^{[1
]}

Patel, K. C. ^{[1
]}

机构：

[1] VNSG Univ, Dept Chem, Surat 395007, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 08期

关键词：

Purine; Thioureido linkage; Minimum inhibitory concentration (MIC); INHIBITORS; POTENT;

D O I：

10.1007/s00044-011-9682-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some new trisubstituted purinyl thioureido were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains and antifungal strain using a micro dilution procedure. Synthesized compounds 6a-j prove to be effective with minimum inhibitory concentration (MIC) (mg ml(-1)), among them 6a, 6d, and 6e showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, H-1-NMR, and elemental analysis.

引用

页码：1660 / 1664

页数：5

共 50 条

[31] Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia
Bertrand, Jeanluc
Dostalova, Hana
Krystof, Vladimir
Jorda, Radek
Delgado, Thalia
Castro-Alvarez, Alejandro
Mella, Jaime
Cabezas, David
Faundez, Mario
Espinosa-Bustos, Christian
Salas, Cristian O.
PHARMACEUTICS, 2022, 14 (06)
[32] A Novel Series of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors
Gucky, Tomas
Jorda, Radek
Zatloukal, Marek
Bazgier, Vaclav
Berka, Karel
Reznickova, Eva
Beres, Tibor
Strnad, Miroslav
Krystof, Vladimir
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (15) : 6234 - 6247
[33] Novel solid-phase preparation of 2,6,9-trisubstituted purines for combinatorial library generation
Dorff, PH
Garigipati, RS
TETRAHEDRON LETTERS, 2001, 42 (15) : 2771 - 2773
[34] Antimicrobial activity and DNA/HSA interaction of fluorinated 3,6,9-trisubstituted acridines
Nunhart, Patrik
Konkolova, Eva
Janovec, Ladislav
Kasparkova, Jana
Malina, Jaroslav
Brabec, Viktor
Matejova, Maria
Miltakova, Beata
Novotny, Ladislav
Phillips, Oludotun A.
Udo, Edet
Kozurkova, Maria
CHEMICAL PAPERS, 2020, 74 (07): : 2327 - 2337
[35] Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis
Raynaud, FI
Fischer, PM
Nutley, BP
Goddard, PM
Lane, DP
Workman, P
MOLECULAR CANCER THERAPEUTICS, 2004, 3 (03) : 353 - 362
[36] 2,6,9-trisubstituted purines: Optimization towards highly potent and selective CDK1 inhibitors
Imbach, P
Capraro, HG
Furet, P
Mett, H
Meyer, T
Zimmermann, J
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (01) : 91 - 96
[37] Correction to: Antimicrobial activity and DNA/HSA interaction of fluorinated 3,6,9-trisubstituted acridines
Patrik Nunhart
Eva Konkoľová
Ladislav Janovec
Jana Kašpárková
Jaroslav Malina
Viktor Brabec
Mária Matejová
Beata Miltáková
Ladislav Novotny
Oludotun A. Phillips
Edet Udo
Mária Kozurkova
Chemical Papers, 2020, 74 : 2339 - 2339
[38] Bone-targeted 2,6,9-trisubstituted purines: Novel inhibitors of Src tyrosine kinase for the treatment of bone diseases
Wang, YH
Metcalf, CA
Shakespeare, WC
Sundaramoorthi, R
Keenan, TP
Bohacek, RS
van Schravendijk, MR
Violette, SM
Narula, SS
Dalgarno, DC
Haraldson, C
Keats, J
Liou, S
Mani, U
Pradeepan, S
Ram, M
Adams, S
Weigele, M
Sawyer, TK
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (18) : 3067 - 3070
[39] Synthesis and antimicrobial activity evaluation of some new adamantane derivatives
Çalis, Ü
Yarim, M
Köksal, M
Özalp, M
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2002, 52 (10): : 778 - 781
[40] Synthesis of some novel Carbazole derivatives and evaluation of their antimicrobial activity
Kaplancikli, Zafer Asim
MARMARA PHARMACEUTICAL JOURNAL, 2011, 15 (03) : 105 - 109

← 1 2 3 4 5 →