Design, synthesis of some 2,6,9-trisubstituted purinyl thioureido derivatives and evaluation of antimicrobial activity

被引：11

作者：

Modi, Jigisha A. ^{[1
]}

Patel, K. C. ^{[1
]}

机构：

[1] VNSG Univ, Dept Chem, Surat 395007, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 08期

关键词：

Purine; Thioureido linkage; Minimum inhibitory concentration (MIC); INHIBITORS; POTENT;

D O I：

10.1007/s00044-011-9682-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some new trisubstituted purinyl thioureido were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains and antifungal strain using a micro dilution procedure. Synthesized compounds 6a-j prove to be effective with minimum inhibitory concentration (MIC) (mg ml(-1)), among them 6a, 6d, and 6e showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, H-1-NMR, and elemental analysis.

引用

页码：1660 / 1664

页数：5

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