Design, synthesis of some 2,6,9-trisubstituted purinyl thioureido derivatives and evaluation of antimicrobial activity

被引：11
|
作者：
Modi, Jigisha A. [1 ]
Patel, K. C. [1 ]
机构：
[1] VNSG Univ, Dept Chem, Surat 395007, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 08期
关键词：
Purine; Thioureido linkage; Minimum inhibitory concentration (MIC); INHIBITORS; POTENT;
D O I：
10.1007/s00044-011-9682-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some new trisubstituted purinyl thioureido were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains and antifungal strain using a micro dilution procedure. Synthesized compounds 6a-j prove to be effective with minimum inhibitory concentration (MIC) (mg ml(-1)), among them 6a, 6d, and 6e showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, H-1-NMR, and elemental analysis.
引用
收藏
页码：1660 / 1664
页数：5
相关论文
共 50 条
  • [1] Design, synthesis of some 2,6,9-trisubstituted purinyl thioureido derivatives and evaluation of antimicrobial activity
    Jigisha A. Modi
    K. C. Patel
    Medicinal Chemistry Research, 2012, 21 : 1660 - 1664
  • [2] Synthesis and activity of 2,6,9-trisubstituted purines
    Schow, SR
    Mackman, RL
    Blum, CL
    Brooks, E
    Horsma, AG
    Joly, A
    Kerwar, SS
    Lee, G
    Shiffman, D
    Nelson, MG
    Wang, XB
    Wick, MM
    Zhang, XM
    Lum, RT
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (21) : 2697 - 2702
  • [3] SYNTHESES OF 2,6,9-TRISUBSTITUTED PURINES AND THEIR ANTIVIRAL ACTIVITY
    BHAKUNI, DS
    GUPTA, PK
    CHOWDHURY, BL
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1984, 23 (12): : 1286 - 1288
  • [4] Synthesis, antitumoral activity, and in silico studies on Smoothened receptor of new 2,6,9-trisubstituted purine derivatives
    Espinosa-Bustos, Christian
    Zarate, Ana-Maria
    Castro-Alvarez, Alejandro
    Guerrero, Simon
    Kogan, Marcelo J.
    Salas, Cristian O.
    JOURNAL OF MOLECULAR STRUCTURE, 2025, 1328
  • [5] Solution-Phase Synthesis of 2,6,9-Trisubstituted Purines
    Tetrahedron Lett, 13 (1827):
  • [6] Exploring novel A2AAR antagonists: Design, synthesis, and evaluation of 2,6,9-trisubstituted purine derivatives as promising antifibrotic agents
    Sun, Jingyang
    Kim, Seojeong
    Park, Seojeong
    Hwang, Seohui
    Sheen, Naeun
    Kim, Soobin
    Kwon, Youngjoo
    Ryu, Jae-Sang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 112
  • [7] Solution-phase synthesis of 2,6,9-trisubstituted purines
    Fiorini, MT
    Abell, C
    TETRAHEDRON LETTERS, 1998, 39 (13) : 1827 - 1830
  • [8] One-Pot Regioselective Synthesis of 2,6,9-Trisubstituted Adenines
    Senhoraes, Nadia
    Dias, Alice M.
    Miguel Conde, L.
    Fernanda Proenca, M.
    SYNLETT, 2011, (02) : 181 - 186
  • [9] Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors
    Vlkova, Kristyna
    Gucky, Tomas
    Perina, Miroslav
    Reznickova, Eva
    Krystof, Vladimir
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 60
  • [10] 2,6,9-Trisubstituted purine derivatives as protein A mimetics for the treatment of autoimmune diseases
    Zacharie, Boulos
    Fortin, Daniel
    Wilb, Nicole
    Bienvenu, Jean-Francois
    Asselin, Michel
    Grouix, Brigitte
    Penney, Christopher
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (01) : 242 - 246
12345