Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors

被引：72
|
作者：
Sewell, Duane A. [1 ]
Pan, Zhen Kun [2 ]
Paterson, Yvonne [2 ]
机构：
[1] Univ Penn, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA
来源：
VACCINE | 2008年 / 26卷 / 41期
基金：
美国国家卫生研究院;
关键词：
Cancer vaccines; Listeria; HPV-16;
D O I：
10.1016/j.vaccine.2008.07.036
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have shown that Listeria-based cancer vaccines inhibit the growth of transplanted tumors in a transgenic mouse model of immune tolerance where HPV-16 E7 is expressed in the thyroid gland. In this study we determine whether these vaccines are able to inhibit autochthonous tumor growth in this animal model. Mice treated with Listeria vaccines expressing E7 had significantly smaller thyroid tumors than did mice treated with controls and possessed higher numbers of antigen-specific CD8(+) T cells within the spleens, tumors, and peripheral blood. This study shows that Listeria-based vaccines are able to slow autochthonous tumor growth and break immunological tolerance. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5315 / 5320
页数：6
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