The efficacy of a DNA vaccine containing inserted and replicated regions of the E7 gene for treatment of HPV-16 induced tumors

被引：26
|
作者：
Brinkman, Joeli A.
Xu, Xuemei
Kast, W. Martin
机构：
[1] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
[2] Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Dept Biophys & Struct Biol, Beijing 100037, Peoples R China
来源：
VACCINE | 2007年 / 25卷 / 17期
关键词：
Human Papillomavirus (HPV); DNA vaccine; cervical cancer;
D O I：
10.1016/j.vaccine.2006.12.045
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A majority of cervical cancers are associated with Human Papillomavirus (HPV)-16. A DNA vaccine (E7IR) was designed for prophylactic and therapeutic treatment of HPV-16+ tumors containing two repeats of the E7 gene to inactivate transformation and duplicate available epitopes. Mice were vaccinated then tumor challenged, or challenged and then immunized and monitored for tumor volume and survival. Splenocytes were utilized for in vivo CTL assays. The E7IR vaccine demonstrated decreased tumor Volume and enhanced survival in prophylactic and therapeutic experiments and improved CTL-mediated lysis. The E71R vaccine shows promise in prevention of tumor formation and elimination of established tumors. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3437 / 3444
页数：8
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