CONSERVATION OF HPV-16 E6/E7 ORF SEQUENCES IN A CERVICAL-CARCINOMA

被引：19
|
作者：
CONE, RW
MINSON, AC
SMITH, MR
MCDOUGALL, JK
机构：
[1] FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA
[2] FIRST HILL WOMENS CLIN, SEATTLE, WA USA
来源：
JOURNAL OF MEDICAL VIROLOGY | 1992年 / 37卷 / 02期
关键词：
HUMAN PAPILLOMAVIRUS; GENITAL; CANCER;
D O I：
10.1002/jmv.1890370205
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A cervical carcinoma that contained human papillomavirus (HPV)-16 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV-16 DNA. The E6 and E7 open reading frames (ORFs) were completely conserved relative to other published HPV-16 sequences. Much of the non-coding region (NCR) was free of base changes, including complete conservation of several regulatory elements. Multiple mutations were identified in the remaining integrated HPV-16 DNA, which was composed of parts of the L1 and E1 ORFs. The extraordinary conservation of the E6/E7 DNA sequence, as compared with other regions of the integrated HPV-16 DNA, supports the role of E6/E7 in tumorigenesis.
引用
收藏
页码：99 / 107
页数：9
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