CONSERVATION OF HPV-16 E6/E7 ORF SEQUENCES IN A CERVICAL-CARCINOMA

被引：19
|
作者：
CONE, RW
MINSON, AC
SMITH, MR
MCDOUGALL, JK
机构：
[1] FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA
[2] FIRST HILL WOMENS CLIN, SEATTLE, WA USA
来源：
JOURNAL OF MEDICAL VIROLOGY | 1992年 / 37卷 / 02期
关键词：
HUMAN PAPILLOMAVIRUS; GENITAL; CANCER;
D O I：
10.1002/jmv.1890370205
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A cervical carcinoma that contained human papillomavirus (HPV)-16 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV-16 DNA. The E6 and E7 open reading frames (ORFs) were completely conserved relative to other published HPV-16 sequences. Much of the non-coding region (NCR) was free of base changes, including complete conservation of several regulatory elements. Multiple mutations were identified in the remaining integrated HPV-16 DNA, which was composed of parts of the L1 and E1 ORFs. The extraordinary conservation of the E6/E7 DNA sequence, as compared with other regions of the integrated HPV-16 DNA, supports the role of E6/E7 in tumorigenesis.
引用
收藏
页码：99 / 107
页数：9
相关论文
共 50 条
  • [31] Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells
    Man Sub Kim
    Yesol Bak
    Yun Sun Park
    Dong Hun Lee
    Jung Hee Kim
    Jeong Woo Kang
    Hyuk-Hwan Song
    Sei-Ryang Oh
    Do Young Yoon
    Cell Biology and Toxicology, 2013, 29 : 259 - 272
  • [32] Genetic Diversity of HPV-16 E6, E7, and L1 Genes in Women With Cervical Lesions in Liaoning Province, China
    Sun, Zhengrong
    Ren, Gaowei
    Cui, Xin
    Zhou, Weiqiang
    Liu, Chao
    Ruan, Qiang
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2011, 21 (03) : 551 - 558
  • [33] Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells
    Kim, Man Sub
    Bak, Yesol
    Park, Yun Sun
    Lee, Dong Hun
    Kim, Jung Hee
    Kang, Jeong Woo
    Song, Hyuk-Hwan
    Oh, Sei-Ryang
    Yoon, Do Young
    CELL BIOLOGY AND TOXICOLOGY, 2013, 29 (04) : 259 - 272
  • [34] RIPOR2 Expression Decreased by HPV-16 E6 and E7 Oncoproteins: An Opportunity in the Search for Prognostic Biomarkers in Cervical Cancer
    Olmedo-Nieva, Leslie
    Omar Munoz-Bello, J.
    Martinez-Ramirez, Imelda
    Daniel Martinez-Gutierrez, Antonio
    Ortiz-Pedraza, Yunuen
    Gonzalez-Espinosa, Claudia
    Madrid-Marina, Vicente
    Torres-Poveda, Kirvis
    Bahena-Roman, Margarita
    Lizano, Marcela
    CELLS, 2022, 11 (23)
  • [35] Seropositivity of HPV 16 E6 and E7 and the risk of oral cancer
    Wong, G. R.
    Ha, K. O.
    Himratul-Aznita, W. H.
    Yang, Y. H.
    Mustafa, W. M. Wan
    Yuen, K. M.
    Abraham, M. T.
    Tay, K. K.
    Karen-Ng, L. P.
    Cheong, S. C.
    Zain, R. B.
    ORAL DISEASES, 2014, 20 (08) : 762 - 767
  • [36] HPV-16 E6/E7 promotes cell migration and invasion in cervical cancer via regulating cadherin switch in vitro and in vivo
    Hu, Dongxiao
    Zhou, Jiansong
    Wang, Fenfen
    Shi, Haiyan
    Li, Yang
    Li, Baohua
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2015, 292 (06) : 1345 - 1354
  • [37] HPV-16 E6/E7 promotes cell migration and invasion in cervical cancer via regulating cadherin switch in vitro and in vivo
    Dongxiao Hu
    Jiansong Zhou
    Fenfen Wang
    Haiyan Shi
    Yang Li
    Baohua Li
    Archives of Gynecology and Obstetrics, 2015, 292 : 1345 - 1354
  • [38] Antibodies against oncoproteins E6 and E7 of human papillomavirus types 16 and 18 in cervical-carcinoma patients from Russia
    Zumbach, K
    Kisseljov, F
    Sacharova, O
    Shaichaev, G
    Semjonova, L
    Pavlova, L
    Pawlita, M
    INTERNATIONAL JOURNAL OF CANCER, 2000, 85 (03) : 313 - 318
  • [39] Tissue engineered cartilage chondrocytes immortalized using human articular by HPV-16 E6 and E7 genes
    Chen, WH
    Lai, WF
    Deng, WP
    Yang, WK
    Lo, WC
    Wu, CC
    Yang, DM
    Lai, MT
    Lin, CT
    Lin, TW
    Yang, CB
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 76A (03) : 512 - 520
  • [40] Comparison of in vitro translated HPV-16 E7 protein with GST-fusion HPV-16 E7 protein as serologic markers in patients with cervical cancer
    Park, JS
    Um, SJ
    Kim, TY
    Kim, EJ
    Kim, CJ
    Park, SN
    Namkoong, SE
    Kim, SJ
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 1998, 8 (05) : 380 - 386
12345