Dopamine-containing gadolinium complex as magnetic resonance imaging contrast agent

被引：12

作者：

Zhou Xin ^{[1
]}

Yang Lian ^{[2
]}

Yan Guoping ^{[1
]}

Xu Wei ^{[1
]}

Zhou Chengkai ^{[2
]}

Zhang Qiao ^{[1
]}

Li Liang ^{[1
]}

Liu Fan ^{[1
]}

Guo Junfang ^{[1
]}

Zhao Qi ^{[1
]}

机构：

[1] Wuhan Inst Technol, Sch Mat Sci & Engn, Wuhan 430074, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Ctr Magnet Resonance Imaging, Wuhan 430022, Peoples R China

来源：

JOURNAL OF RARE EARTHS | 2012年 / 30卷 / 09期

基金：

中国国家自然科学基金;

关键词：

magnetic resonance imaging (MRI); contrast agent; gadolinium complex; diethylenetriaminepentaacetic acid; dopamine; brain; rare earths; BLOOD-BRAIN-BARRIER; DENDRIMERS; EPILEPSY;

D O I：

10.1016/S1002-0721(12)60150-1

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Gadolinium diethylenetriamine-pentaacetic bisdopamide (Gd-DTPA-2DA) was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid (DTPA) and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and produced highly contrasted visualization of the brain.

引用

页码：884 / 889

页数：6

共 50 条

[41] Gadolinium (III)-Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent
Chen, Xiangyu
Teng, Shiyong
Li, Jinming
Qiao, Xuezhi
Zhao, Weidong
Xue, Zhengjie
Shi, Xudong
Wang, Yuguang
Yang, Wensheng
Wang, Tie
ADVANCED MATERIALS, 2023, 35 (20)
[42] Gadolinium complexes containing polyamino polycarboxylate ligands for Magnetic Resonance Imaging (MRI) contrast agents
Wong, WT
JOURNAL OF INORGANIC BIOCHEMISTRY, 2003, 96 (01) : 22 - 22
[43] Porphyrin-containing polyaspartamide gadolinium complexes as potential magnetic resonance imaging contrast agents
Yan, Guo-Ping
Li, Zhen
Xu, Wei
Zhou, Cheng-Kai
Yang, Lian
Zhang, Qiao
Li, Liang
Liu, Fan
Han, Lin
Ge, Yuan-Xing
Guo, Jun-Fang
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 407 (1-2) : 119 - 125
[44] Preparation of Magnetic Resonance Contrast Agent Gadolinium-Containing Organic Nanoparticles and Their Electrochemical Behavior Investigation
Kang, Yongkun
Zhaoz, Yanjuan
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2022, 17 (07):
[45] Use of Intravenous Gadolinium Contrast in Equine Magnetic Resonance Imaging
Saveraid, Travis C.
Judy, Carter E.
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 2012, 28 (03) : 617 - +
[46] Evaluation of a quercetin-gadolinium complex as an efficient positive contrast enhancer for magnetic resonance imaging
Muthurajan, Thenmozhi
Rammanohar, Pooja
Rajendran, Nisha Palanisamy
Sethuraman, Swaminathan
Krishnan, Uma Maheswari
RSC ADVANCES, 2015, 5 (106) : 86967 - 86979
[47] Information for Gadolinium-Contrast Agents for Magnetic Resonance Imaging
不详
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2016, 188 (04): : 414 - 414
[48] New gadolinium complexes as magnetic resonance imaging - Contrast agents
Wagner, M
Ruloff, R
Hoyer, E
Grunder, W
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 1997, 52 (7-8): : 508 - 515
[49] Rapid deterioration of renal insufficiency after magnetic resonance imaging with gadolinium-based contrast agent
Fujisaki, K.
Ono-Fujisaki, A.
Kura-Nakamura, N.
Komune, N.
Hirakawa, N.
Tsuruya, K.
Komune, S.
Iida, M.
CLINICAL NEPHROLOGY, 2011, 75 (03) : 251 - 254
[50] A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging
Mouffouk, Fouzi
Serrai, Hacene
Bhaduri, Sourav
Achten, Rik
Seyyedhamzeh, Mozhdeh
Husain, Ali A.
Alhendal, Abdullah
Zourob, Mohammed
MOLECULES, 2020, 25 (07):

← 1 2 3 4 5 →