Dopamine-containing gadolinium complex as magnetic resonance imaging contrast agent

被引：12
|
作者：
Zhou Xin [1 ]
Yang Lian [2 ]
Yan Guoping [1 ]
Xu Wei [1 ]
Zhou Chengkai [2 ]
Zhang Qiao [1 ]
Li Liang [1 ]
Liu Fan [1 ]
Guo Junfang [1 ]
Zhao Qi [1 ]
机构：
[1] Wuhan Inst Technol, Sch Mat Sci & Engn, Wuhan 430074, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Ctr Magnet Resonance Imaging, Wuhan 430022, Peoples R China
来源：
JOURNAL OF RARE EARTHS | 2012年 / 30卷 / 09期
基金：
中国国家自然科学基金;
关键词：
magnetic resonance imaging (MRI); contrast agent; gadolinium complex; diethylenetriaminepentaacetic acid; dopamine; brain; rare earths; BLOOD-BRAIN-BARRIER; DENDRIMERS; EPILEPSY;
D O I：
10.1016/S1002-0721(12)60150-1
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Gadolinium diethylenetriamine-pentaacetic bisdopamide (Gd-DTPA-2DA) was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid (DTPA) and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and produced highly contrasted visualization of the brain.
引用
收藏
页码：884 / 889
页数：6
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