Dopamine-containing gadolinium complex as magnetic resonance imaging contrast agent

被引：12

作者：

Zhou Xin ^{[1
]}

Yang Lian ^{[2
]}

Yan Guoping ^{[1
]}

Xu Wei ^{[1
]}

Zhou Chengkai ^{[2
]}

Zhang Qiao ^{[1
]}

Li Liang ^{[1
]}

Liu Fan ^{[1
]}

Guo Junfang ^{[1
]}

Zhao Qi ^{[1
]}

机构：

[1] Wuhan Inst Technol, Sch Mat Sci & Engn, Wuhan 430074, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Ctr Magnet Resonance Imaging, Wuhan 430022, Peoples R China

来源：

JOURNAL OF RARE EARTHS | 2012年 / 30卷 / 09期

基金：

中国国家自然科学基金;

关键词：

magnetic resonance imaging (MRI); contrast agent; gadolinium complex; diethylenetriaminepentaacetic acid; dopamine; brain; rare earths; BLOOD-BRAIN-BARRIER; DENDRIMERS; EPILEPSY;

D O I：

10.1016/S1002-0721(12)60150-1

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Gadolinium diethylenetriamine-pentaacetic bisdopamide (Gd-DTPA-2DA) was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid (DTPA) and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and produced highly contrasted visualization of the brain.

引用

页码：884 / 889

页数：6

共 50 条

[31] A smart copper(II)-responsive binuclear gadolinium(III) complex-based magnetic resonance imaging contrast agent
Xiao, Yan-meng
Zhao, Gui-yan
Fang, Xin-xiu
Zhao, Yong-xia
Wang, Guan-hua
Yang, Wei
Xu, Jing-wei
RSC ADVANCES, 2014, 4 (65) : 34421 - 34427
[32] A heteronuclear ZnGd complex as a potential contrast agent for magnetic resonance imaging
Fondo, Matilde
Corredoira, Julio
Garcia-Deibe, Ana M.
Sanmartin, Jesus
Iglesias, Ramon
Taboadac, Pablo
20TH INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY (ECSOC), 2016,
[33] Gadolinium containing contrast agents for pulmonary ventilation magnetic resonance imaging -: Preliminary results
Haage, P
Karaagac, S
Adam, G
Spüntrup, E
Pfeffer, J
Günther, RW
INVESTIGATIVE RADIOLOGY, 2002, 37 (03) : 120 - 125
[34] GADOLINIUM-CONTRAST NEPHROTOXICITY IN MAGNETIC RESONANCE IMAGING
Okamoto, Tomoko
Kamata, Kouju
Naito, Shokichi
Tazaki, Hiromi
Kan, Shinichi
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 : 364 - 364
[35] Gadolinium contrast agent is of limited value for magnetic resonance imaging assessment of synovial hypertrophy in hemophiliacs
Lundin, B.
Berntorp, E.
Pettersson, H.
Wirestam, R.
Jonsson, K.
Stahlberg, F.
Ljung, R.
ACTA RADIOLOGICA, 2007, 48 (05) : 520 - 530
[36] A Novel Gadolinium-Based Trimetasphere Metallofullerene for Application as a Magnetic Resonance Imaging Contrast Agent
Adiseshaiah, Pavan
Dellinger, Anthony
MacFarland, Darren
Stern, Stephan
Dobrovolskaia, Marina
Ileva, Lilia
Patri, Anil K.
Bernardo, Marcelino
Brooks, D. Bradford
Zhou, Zhiguo
McNeil, Scott
Kepley, Christopher
INVESTIGATIVE RADIOLOGY, 2013, 48 (11) : 745 - 754
[37] MAGNETIC-RESONANCE-IMAGING WITH GADOLINIUM CONTRAST AGENT IN SMALL DEEP (LACUNAR) CEREBRAL INFARCTS
REGLI, L
REGLI, F
MAEDER, P
BOGOUSSLAVSKY, J
ARCHIVES OF NEUROLOGY, 1993, 50 (02) : 175 - 180
[38] Synthesis and Characterization of a Novel Gadolinium-Based Contrast Agent for Magnetic Resonance Imaging of Myelination
Frullano, Luca
Zhu, Junqing
Miller, Robert H.
Wang, Yanming
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (04) : 1629 - 1640
[39] A new biodegradable and biocompatible gadolinium (III) -polymer for liver magnetic resonance imaging contrast agent
Xiao, Yan
Xue, Rong
You, Tianyan
Li, Xiaojing
Pei, Fengkui
MAGNETIC RESONANCE IMAGING, 2015, 33 (06) : 822 - 828
[40] Monoclonal antibody conjugated to gadolinium as a contrast agent for magnetic resonance imaging of human rectal carcinoma
Kuriu, Yoshiaki
Otsuji, Eigo
Kin, Syuichi
Nakase, Yuen
Fukuda, Ken-Ichiro
Okamoto, Kazuma
Hagiwara, Akeo
Yamagishi, Hisakazu
JOURNAL OF SURGICAL ONCOLOGY, 2006, 94 (02) : 144 - 148

← 1 2 3 4 5 →