Dopamine-containing gadolinium complex as magnetic resonance imaging contrast agent

被引：12

作者：

Zhou Xin ^{[1
]}

Yang Lian ^{[2
]}

Yan Guoping ^{[1
]}

Xu Wei ^{[1
]}

Zhou Chengkai ^{[2
]}

Zhang Qiao ^{[1
]}

Li Liang ^{[1
]}

Liu Fan ^{[1
]}

Guo Junfang ^{[1
]}

Zhao Qi ^{[1
]}

机构：

[1] Wuhan Inst Technol, Sch Mat Sci & Engn, Wuhan 430074, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Ctr Magnet Resonance Imaging, Wuhan 430022, Peoples R China

来源：

JOURNAL OF RARE EARTHS | 2012年 / 30卷 / 09期

基金：

中国国家自然科学基金;

关键词：

magnetic resonance imaging (MRI); contrast agent; gadolinium complex; diethylenetriaminepentaacetic acid; dopamine; brain; rare earths; BLOOD-BRAIN-BARRIER; DENDRIMERS; EPILEPSY;

D O I：

10.1016/S1002-0721(12)60150-1

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Gadolinium diethylenetriamine-pentaacetic bisdopamide (Gd-DTPA-2DA) was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid (DTPA) and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and produced highly contrasted visualization of the brain.

引用

页码：884 / 889

页数：6

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