An Efficient Synthesis of Racemic Tolterodine

被引：1
|
作者：
Rao, K. Sudarshan [1 ]
Rao, K. Nageswara [1 ]
Muralikrishna, P. [1 ]
Jayashree, A. [1 ]
机构：
[1] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, Andhra Pradesh, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 09期
关键词：
Cost effective; Synthesis; Tolterodine; MUSCARINIC RECEPTOR ANTAGONIST; ASYMMETRIC TOTAL-SYNTHESIS; IN-VITRO; (R)-TOLTERODINE; BLADDER; (+)-TOLTERODINE; CONTRACTION;
D O I：
10.14233/ajchem.2014.15708
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The efficient and cost effective of the synthesis of (+/-)-tolterodine (+), a precursor of (+)-(R)-tolterodine was efficiently performed from 6-methyl-4-chroman-2-one (2) via 4 steps in high yield. This process is suitable for large-scale commercial production by avoiding hazardous reagents and high pressure of hydrogen gas.
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页码：2813 / 2814
页数：2
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