An Efficient Synthesis of Racemic Tolterodine

被引：1

作者：

Rao, K. Sudarshan ^{[1
]}

Rao, K. Nageswara ^{[1
]}

Muralikrishna, P. ^{[1
]}

Jayashree, A. ^{[1
]}

机构：

[1] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, Andhra Pradesh, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 09期

关键词：

Cost effective; Synthesis; Tolterodine; MUSCARINIC RECEPTOR ANTAGONIST; ASYMMETRIC TOTAL-SYNTHESIS; IN-VITRO; (R)-TOLTERODINE; BLADDER; (+)-TOLTERODINE; CONTRACTION;

D O I：

10.14233/ajchem.2014.15708

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The efficient and cost effective of the synthesis of (+/-)-tolterodine (+), a precursor of (+)-(R)-tolterodine was efficiently performed from 6-methyl-4-chroman-2-one (2) via 4 steps in high yield. This process is suitable for large-scale commercial production by avoiding hazardous reagents and high pressure of hydrogen gas.

引用

页码：2813 / 2814

页数：2

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