An Efficient Synthesis of Racemic Tolterodine

被引：1

作者：

Rao, K. Sudarshan ^{[1
]}

Rao, K. Nageswara ^{[1
]}

Muralikrishna, P. ^{[1
]}

Jayashree, A. ^{[1
]}

机构：

[1] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, Andhra Pradesh, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 09期

关键词：

Cost effective; Synthesis; Tolterodine; MUSCARINIC RECEPTOR ANTAGONIST; ASYMMETRIC TOTAL-SYNTHESIS; IN-VITRO; (R)-TOLTERODINE; BLADDER; (+)-TOLTERODINE; CONTRACTION;

D O I：

10.14233/ajchem.2014.15708

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The efficient and cost effective of the synthesis of (+/-)-tolterodine (+), a precursor of (+)-(R)-tolterodine was efficiently performed from 6-methyl-4-chroman-2-one (2) via 4 steps in high yield. This process is suitable for large-scale commercial production by avoiding hazardous reagents and high pressure of hydrogen gas.

引用

页码：2813 / 2814

页数：2

共 50 条

[21] Synthesis of racemic germicidin
Lokot, IP
Pashkovsky, FS
Lakhvich, FA
MENDELEEV COMMUNICATIONS, 1999, (01) : 22 - 23
[22] SYNTHESIS OF RACEMIC DEOXYMYCELIANAMIDE
GALLINA, C
ROMEO, A
TORTOREL.V
DAGNOLO, G
CHEMISTRY & INDUSTRY, 1966, (30) : 1300 - &
[23] THE SYNTHESIS OF RACEMIC AZACARBAPENAMS
TSCHAMBER, T
HENLIN, JM
PIPE, D
STREITH, J
HETEROCYCLES, 1985, 23 (10) : 2589 - 2601
[24] A synthesis of racemic mannitol
Lespieau
Wiemann
COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES, 1932, 194 : 1946 - 1947
[25] SYNTHESIS OF RACEMIC HOMOSARCOMYCINS
JANKOWSKI, K
TETRAHEDRON LETTERS, 1971, (20) : 1733 - +
[26] SYNTHESIS OF RACEMIC LOLIOLIDE
HORII, ZI
YAGAMI, T
ITO, M
HANAOKA, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 1968, 16 (05) : 848 - +
[27] SYNTHESIS OF RACEMIC LOLIOLIDE
HORII, Z
YAGAMI, T
HANAOKA, M
CHEMICAL COMMUNICATIONS, 1966, (18) : 634 - &
[28] SYNTHESIS OF RACEMIC TENELLIN
WILLIAMS, DR
SIT, SY
JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (15): : 2846 - 2851
[29] SYNTHESIS OF RACEMIC SARKOMYCIN
SHEMYAKIN, MM
RAVDEL, GA
CHAMAN, YS
SHVETSOV, YB
VINOGRADOVA, YI
CHEMISTRY & INDUSTRY, 1957, (40) : 1320 - 1321
[30] SYNTHESIS OF RACEMIC SESQUICARENE
MORI, K
MATSUI, M
TETRAHEDRON LETTERS, 1969, (32) : 2729 - &

← 1 2 3 4 5 →