In the current era, manufacturing industries are facing multifaceted challenges related to increasing environmental awareness, decreasing economic gains, and technology obsolesce. These challenges become more apparent during the machining of difficult-to-machine materials due to high tool wear rates, high cutting forces, undesirable surface quality, high tool replacement costs, and a stagnating productivity. The developed approach aims at improving environmental, economic, and technological factors by optimizing four performance characteristics-energy demand, surface roughness, tool wear, and material removal rate during the milling of H13 tool steel by using an integrated artificial neural network and genetic algorithm. The proposed methodology provides Pareto solutions for minimum energy demand, surface roughness, & tool wear, and maximum material removal rate. The novelty of this work lies in generating Pareto fronts for analyzing conflicting responses, and determining preferred solutions without sacrificing environmental, technological, and economic considerations, simultaneously. The present work will be significant to practitioners in adopting better management strategies and simultaneously dealing with these challenges. The potential of the research lies in directly integrating the proposed optimization module with the machine tool system to serve as an online tool for machine tool process optimization.