Predictors of Mortality among Patients Hospitalized with COVID-19 during the First Wave in India: A Multisite Case-Control Study

被引：1

作者：

Krishnan, Anand ^{[1
,36
]}

Kumar, Rakesh ^{[1
]}

Amarchand, Ritvik ^{[1
]}

Mohan, Anant ^{[2
]}

Kant, Ravi ^{[3
]}

Agarwal, Ankit ^{[4
]}

Kulshreshtha, Poorvi ^{[5
]}

Panda, Prasan Kumar ^{[6
]}

Bhadoria, Ajeet Singh ^{[7
]}

Agarwal, Neeraj ^{[8
]}

Biswas, Bijit

Nair, Rathish ^{[9
]}

Wig, Naveet ^{[10
]}

Malhotra, Rajesh ^{[11
]}

Bhatnagar, Sushma ^{[12
]}

Aggarwal, Richa ^{[13
]}

Soni, Kapil Dev ^{[13
]}

Madan, Nirupam ^{[14
]}

Trikha, Anjan ^{[15
]}

Tiwari, Pawan ^{[2
]}

Singh, Angel Rajan ^{[14
]}

Wyawahare, Mukta ^{[16
]}

Gunasekaran, Venugopalan ^{[17
]}

Sekar, Dineshbabu ^{[16
]}

Misra, Sanjeev ^{[18
]}

Bhardwaj, Pankaj ^{[19
]}

Goel, Akhil Dhanesh ^{[19
]}

Dutt, Naveen ^{[20
]}

Kumar, Deepak ^{[21
]}

Nagarkar, Nitin M. ^{[22
]}

Galhotra, Abhiruchi ^{[23
]}

Jindal, Atul ^{[24
]}

Raj, Utsav ^{[25
]}

Behera, Ajoy ^{[26
]}

Siddiqui, Sabbah ^{[27
]}

Kokane, Arun ^{[28
]}

Joshi, Rajnish ^{[29
]}

Pakhare, Abhijit ^{[28
]}

Farooque, Farhan ^{[28
]}

Pawan, Sai ^{[29
]}

Deshmukh, Pradeep ^{[30
]}

Solanki, Ranjan ^{[30
]}

Rathod, Bharatsing ^{[31
]}

Dutta, Vibha ^{[32
]}

Mohapatra, Prasanta Raghab ^{[33
]}

Panigrahi, Manoj Kumar ^{[33
]}

Barik, Sadananda ^{[34
]}

Guleria, Randeep ^{[35
]}

机构：

[1] All India Inst Med Sci AIIMS, Ctr Community Med, New Delhi, India

[2] AIIMS, Dept Pulm Crit Care & Sleep Med, New Delhi, India

[3] AIIMS, Rishikesh, India

[4] AIIMS, Dept Anaesthesia, Rishikesh, India

[5] AIIMS, Dept Physiol, Rishikesh, India

[6] AIIMS, Dept Med, Rishikesh, India

[7] AIIMS, Dept Community & Family Med, Rishikesh, India

[8] AIIMS, Dept Community & Family Med, Patna, India

[9] AIIMS, Coll Nursing, Patna, India

[10] AIIMS, Dept Med, New Delhi, India

[11] AIIMS, Jai Prakash Narayan Apex Trauma Ctr, New Delhi, India

[12] AIIMS, Dept Onco Anaesthesia, BRAIRCH, New Delhi, India

[13] AIIMS, Jai Prakash Narayan Apex Trauma Ctr, Dept Anaesthesia & Crit Care, New Delhi, India

[14] AIIMS, Dept Hosp Adm, New Delhi, India

[15] AIIMS, Dept Anaesthesiol Pain Med & Crit Care, New Delhi, India

[16] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Med, Pondicherry, India

[17] JIPMER, Dept Geriatr Med, Pondicherry, India

[18] AIIMS, Jodhpur, India

[19] AIIMS, Dept Community & Family Med, Jodhpur, India

[20] AIIMS, Dept Pulm Med, Jodhpur, India

[21] AIIMS, Dept Med, Jodhpur, India

[22] AIIMS, Raipur, India

[23] AIIMS, Dept Community & Family Med, Raipur, India

[24] AIIMS, Dept Paediat, Raipur, India

[25] AIIMS, Natl TB Eliminat Program, Raipur, India

[26] AIIMS, Dept Pulm Med, Raipur, India

[27] AIIMS, Dept Med, Raipur, India

[28] AIIMS, Dept Community & Family Med, Bhopal, India

[29] AIIMS, Dept Med, Bhopal, India

[30] AIIMS, Dept Community & Family Med, Nagpur, India

[31] AIIMS, Dept Med, Nagpur, India

[32] AIIMS, Nagpur, India

[33] AIIMS, Dept Pulm Med & Crit Care, Bhubaneswar, India

[34] AIIMS, Dept Trauma & Emergency Med, Bhubaneswar, India

[35] AIIMS, New Delhi, India

[36] All India Inst Med Sci, Ctr Community Med, Room 13,Old OT Block, New Delhi 110029, India

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2023年 / 108卷 / 04期

关键词：

ILLNESS;

D O I：

10.4269/ajtmh.22-0705

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 disease (COVID-19) has caused more than 6 million deaths globally. Understanding predictors of mortality will help in prioritizing patient care and preventive approaches. This was a multicentric, unmatched, hospital-based case-control study conducted in nine teaching hospitals in India. Cases were microbiologically confirmed COVID-19 patients who died in the hospital during the period of study and controls were microbiologically confirmed COVID-19 patients who were discharged from the same hospital after recovery. Cases were recruited sequentially from March 2020 until December-March 2021. All information regarding cases and controls was extracted retrospectively from the medical records of patients by trained physicians. Univariable and multivariable logistic regression was done to assess the association between various predictor variables and deaths due to COVID-19. A total of 2,431 patients (1,137 cases and 1,294 controls) were included in the study. The mean age of patients was 52.8 years (SD: 16.5 years), and 32.1% were females. Breathlessness was the most common symptom at the time of admission (53.2%). Increasing age (adjusted odds ratio [aOR]: 46-59 years, 3.4 [95% CI: 1.5-7.7]; 60-74 years, 4.1 [95% CI: 1.7-9.5]; and $ 75 years, 11.0 [95% CI: 4.0-30.6]); preexisting diabetes mellitus (aOR: 1.9 [95% CI: 1.2-2.9]); malignancy (aOR: 3.1 [95% CI: 1.3-7.8]); pulmonary tuberculosis (aOR: 3.3 [95% CI: 1.2-8.8]); breathlessness at the time of admission (aOR: 2.2 [95% CI: 1.4-3.5]); high quick Sequential Organ Failure Assessment score at the time of admission (aOR: 5.6 [95% CI: 2.7-11.4]); and oxygen saturation , 94% at the time of admission (aOR: 2.5 [95% CI: 1.6-3.9]) were associated with mortality due to COVID-19. These results can be used to prioritize patients who are at increased risk of death and to rationalize therapy to reduce mortality due to COVID-19.

引用

页码：727 / 733

页数：7

共 50 条

[41] Admission Predictors of Mortality in Hospitalized COVID-19 Patients-A Serbian Cohort Study
Poskurica, Mina
Stevanovic, Dorde
Zdravkovic, Vladimir
Cekerevac, Ivan
Cupurdija, Vojislav
Zdravkovic, NebojSa
Nikolic, Tomislav
Markovic, Marina
Jovanovic, Marina
Popovic, Marija
Vesic, Katarina
Arsic, Ana Azanjac
Lazarevic, Snezana
Jevtovic, Andra
Patrnogic, Aleksandar
Andelkovic, Marija
Petrovic, Marina
JOURNAL OF CLINICAL MEDICINE, 2022, 11 (20)
[42] First and second wave of COVID-19 in Tunisia:A comparative study among patients hospitalized in a medicine department
Jbeli, Rihab
Louhaichi, Sabrine
Khlfallah, Ikbel
Marzouki, Safa
Kaabi, Line
Elfidha, Sabrine
Ammar, Jamel
Hamdi, Besma
Hamzaoui, Agnes
EUROPEAN RESPIRATORY JOURNAL, 2021, 58
[43] Predictors of mortality among hospitalized patients with COVID-19: A single-centre retrospective analysis
Pranshu, Kumar
Shahul, Aneesa
Singh, Surjit
Kuwal, Ashok
Sonigra, Maldev
Dutt, Naveen
CANADIAN JOURNAL OF RESPIRATORY THERAPY, 2022, 58 (01): : 98 - 102
[44] Prevalence and Predictors of Venous Thromboembolism or Mortality in Hospitalized COVID-19 Patients
Cohen, Stuart L.
Gianos, Eugenia
Barish, Mathew A.
Chatterjee, Saurav
Kohn, Nina
Lesser, Martin
Giannis, Dimitrios
Coppa, Kevin
Hirsch, Jamie S.
McGinn, Thomas G.
Goldin, Mark E.
Spyropoulos, Alex C.
THROMBOSIS AND HAEMOSTASIS, 2021, 121 (08) : 1043 - 1053
[45] Predictors of mortality in hospitalized African American COVID-19 patients with cancer
Challa, Suryanarayana Reddy
Oskrochi, Gholamreza
Singh, Gagan Paul
Chirumamilla, Lakshmi G.
Shayegh, Nader
Nair, Vaisakh K.
Littleton, Megan
Byer, Danae T.
Morrison, Nicole A.
Grossi, Brittany L.
Ashanna, Barclay
Dusmatova, Shahnoza
Thompson, Trae
Dawodu, Dideolu O.
Brim, Hassan
Ashktorab, Hassan
TRANSLATIONAL CANCER RESEARCH, 2024, 13 (03) : 1314 - 1322
[46] Predictors of mortality of hospitalized COVID-19 pneumonia patients in university hospital
Wafy, Safa M.
Saman, Marina O.
Ahmed, Mostafa K.
EGYPTIAN JOURNAL OF BRONCHOLOGY, 2024, 18 (01)
[47] Clinical profiles and mortality predictors of hospitalized patients with COVID-19 in Ethiopia
Abera, Eyob Girma
Tukeni, Kedir Negesso
Chala, Temesgen Kabeta
Yilma, Daniel
Gudina, Esayas Kebede
BMC INFECTIOUS DISEASES, 2024, 24 (01)
[48] Predictors of mortality of hospitalized COVID-19 pneumonia patients in university hospital
Safa M. Wafy
Marina O. Saman
Mostafa K. Ahmed
The Egyptian Journal of Bronchology, 18
[49] Predictors of Mortality among COVID-19 Patients- A Case Control Study at Tertiary Care Center, Nanded (Maharashtra)
Gattani, Prakash L.
Nakel, Mahavir P.
Inamdar, Ismail F.
Maidapwad, Sainath L.
Damkondwar, Omprasad B.
Warkad, Komal S.
Butte, Rajabhau S.
Bansode, Abhijeet L.
INDIAN JOURNAL OF COMMUNITY MEDICINE, 2023, 48 (02) : 230 - 237
[50] FIRST EXPERIENCE OF BAMLANIVIMAB FOR COVID-19 POSITIVE HAEMODIALYSIS PATIENTS: A CASE-CONTROL STUDY
Djuric, Petar
Bogicevic, Jovana
Pesic, Snezana
Davidovic, Zeljko
Naumovic, Radomir
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2022, 37 : I481 - I482

← 1 2 3 4 5 →