Predictors of Mortality among Patients Hospitalized with COVID-19 during the First Wave in India: A Multisite Case-Control Study

被引：1

作者：

Krishnan, Anand ^{[1
,36
]}

Kumar, Rakesh ^{[1
]}

Amarchand, Ritvik ^{[1
]}

Mohan, Anant ^{[2
]}

Kant, Ravi ^{[3
]}

Agarwal, Ankit ^{[4
]}

Kulshreshtha, Poorvi ^{[5
]}

Panda, Prasan Kumar ^{[6
]}

Bhadoria, Ajeet Singh ^{[7
]}

Agarwal, Neeraj ^{[8
]}

Biswas, Bijit

Nair, Rathish ^{[9
]}

Wig, Naveet ^{[10
]}

Malhotra, Rajesh ^{[11
]}

Bhatnagar, Sushma ^{[12
]}

Aggarwal, Richa ^{[13
]}

Soni, Kapil Dev ^{[13
]}

Madan, Nirupam ^{[14
]}

Trikha, Anjan ^{[15
]}

Tiwari, Pawan ^{[2
]}

Singh, Angel Rajan ^{[14
]}

Wyawahare, Mukta ^{[16
]}

Gunasekaran, Venugopalan ^{[17
]}

Sekar, Dineshbabu ^{[16
]}

Misra, Sanjeev ^{[18
]}

Bhardwaj, Pankaj ^{[19
]}

Goel, Akhil Dhanesh ^{[19
]}

Dutt, Naveen ^{[20
]}

Kumar, Deepak ^{[21
]}

Nagarkar, Nitin M. ^{[22
]}

Galhotra, Abhiruchi ^{[23
]}

Jindal, Atul ^{[24
]}

Raj, Utsav ^{[25
]}

Behera, Ajoy ^{[26
]}

Siddiqui, Sabbah ^{[27
]}

Kokane, Arun ^{[28
]}

Joshi, Rajnish ^{[29
]}

Pakhare, Abhijit ^{[28
]}

Farooque, Farhan ^{[28
]}

Pawan, Sai ^{[29
]}

Deshmukh, Pradeep ^{[30
]}

Solanki, Ranjan ^{[30
]}

Rathod, Bharatsing ^{[31
]}

Dutta, Vibha ^{[32
]}

Mohapatra, Prasanta Raghab ^{[33
]}

Panigrahi, Manoj Kumar ^{[33
]}

Barik, Sadananda ^{[34
]}

Guleria, Randeep ^{[35
]}

机构：

[1] All India Inst Med Sci AIIMS, Ctr Community Med, New Delhi, India

[2] AIIMS, Dept Pulm Crit Care & Sleep Med, New Delhi, India

[3] AIIMS, Rishikesh, India

[4] AIIMS, Dept Anaesthesia, Rishikesh, India

[5] AIIMS, Dept Physiol, Rishikesh, India

[6] AIIMS, Dept Med, Rishikesh, India

[7] AIIMS, Dept Community & Family Med, Rishikesh, India

[8] AIIMS, Dept Community & Family Med, Patna, India

[9] AIIMS, Coll Nursing, Patna, India

[10] AIIMS, Dept Med, New Delhi, India

[11] AIIMS, Jai Prakash Narayan Apex Trauma Ctr, New Delhi, India

[12] AIIMS, Dept Onco Anaesthesia, BRAIRCH, New Delhi, India

[13] AIIMS, Jai Prakash Narayan Apex Trauma Ctr, Dept Anaesthesia & Crit Care, New Delhi, India

[14] AIIMS, Dept Hosp Adm, New Delhi, India

[15] AIIMS, Dept Anaesthesiol Pain Med & Crit Care, New Delhi, India

[16] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Med, Pondicherry, India

[17] JIPMER, Dept Geriatr Med, Pondicherry, India

[18] AIIMS, Jodhpur, India

[19] AIIMS, Dept Community & Family Med, Jodhpur, India

[20] AIIMS, Dept Pulm Med, Jodhpur, India

[21] AIIMS, Dept Med, Jodhpur, India

[22] AIIMS, Raipur, India

[23] AIIMS, Dept Community & Family Med, Raipur, India

[24] AIIMS, Dept Paediat, Raipur, India

[25] AIIMS, Natl TB Eliminat Program, Raipur, India

[26] AIIMS, Dept Pulm Med, Raipur, India

[27] AIIMS, Dept Med, Raipur, India

[28] AIIMS, Dept Community & Family Med, Bhopal, India

[29] AIIMS, Dept Med, Bhopal, India

[30] AIIMS, Dept Community & Family Med, Nagpur, India

[31] AIIMS, Dept Med, Nagpur, India

[32] AIIMS, Nagpur, India

[33] AIIMS, Dept Pulm Med & Crit Care, Bhubaneswar, India

[34] AIIMS, Dept Trauma & Emergency Med, Bhubaneswar, India

[35] AIIMS, New Delhi, India

[36] All India Inst Med Sci, Ctr Community Med, Room 13,Old OT Block, New Delhi 110029, India

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2023年 / 108卷 / 04期

关键词：

ILLNESS;

D O I：

10.4269/ajtmh.22-0705

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 disease (COVID-19) has caused more than 6 million deaths globally. Understanding predictors of mortality will help in prioritizing patient care and preventive approaches. This was a multicentric, unmatched, hospital-based case-control study conducted in nine teaching hospitals in India. Cases were microbiologically confirmed COVID-19 patients who died in the hospital during the period of study and controls were microbiologically confirmed COVID-19 patients who were discharged from the same hospital after recovery. Cases were recruited sequentially from March 2020 until December-March 2021. All information regarding cases and controls was extracted retrospectively from the medical records of patients by trained physicians. Univariable and multivariable logistic regression was done to assess the association between various predictor variables and deaths due to COVID-19. A total of 2,431 patients (1,137 cases and 1,294 controls) were included in the study. The mean age of patients was 52.8 years (SD: 16.5 years), and 32.1% were females. Breathlessness was the most common symptom at the time of admission (53.2%). Increasing age (adjusted odds ratio [aOR]: 46-59 years, 3.4 [95% CI: 1.5-7.7]; 60-74 years, 4.1 [95% CI: 1.7-9.5]; and $ 75 years, 11.0 [95% CI: 4.0-30.6]); preexisting diabetes mellitus (aOR: 1.9 [95% CI: 1.2-2.9]); malignancy (aOR: 3.1 [95% CI: 1.3-7.8]); pulmonary tuberculosis (aOR: 3.3 [95% CI: 1.2-8.8]); breathlessness at the time of admission (aOR: 2.2 [95% CI: 1.4-3.5]); high quick Sequential Organ Failure Assessment score at the time of admission (aOR: 5.6 [95% CI: 2.7-11.4]); and oxygen saturation , 94% at the time of admission (aOR: 2.5 [95% CI: 1.6-3.9]) were associated with mortality due to COVID-19. These results can be used to prioritize patients who are at increased risk of death and to rationalize therapy to reduce mortality due to COVID-19.

引用

页码：727 / 733

页数：7

共 50 条

[21] Evaluation of mortality predictors in hospitalized COVID-19 patients: Retrospective cohort study
Sener, Melahat Uzel
Yildiz, Murat
Kavurgaci, Suna
Ergur, Figen Ozturk
Sener, Alp
Ozturk, Ayperi
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX, 2021, 69 (02): : 196 - 206
[22] The healthy behaviours and COVID-19 mortality among Iranian women: a case-control study
Pourfarzi, Farhad
Pouran, Shima Rahim
Dargahi, Abdollah
Karami, Chiman
Fouladi, Nasrin
Zandian, Hamed
Moghadam, Telma Zahirian
BMC WOMENS HEALTH, 2021, 21 (01)
[23] Clinical and Laboratory Predictors of Mortality in Hospitalized COVID-19 Patients
Riahi, Taghi
Shokri, Sima
Faiz, Seyed Hamid Reza
Hemati, Karim
Mousavie, Seyed Hamzeh
Baghestani, Amir
Khazaeian, Ali
Hassanlouei, Babak
IRANIAN RED CRESCENT MEDICAL JOURNAL, 2021, 23 (05)
[24] Predictors of Mortality Among Hospitalized COVID-19 Patients at a Tertiary Care Hospital in Ethiopia
Ayana, Galana Mamo
Merga, Bedasa Taye
Birhanu, Abdi
Alemu, Addisu
Negash, Belay
Dessie, Yadeta
INFECTION AND DRUG RESISTANCE, 2021, 14 : 5363 - 5373
[25] Mortality over time among COVID-19 patients hospitalized during the first surge of the pandemic: A large cohort study
Marcilio, Izabel
Lazar Neto, Felippe
Cortez, Andre Lazzeri
Miethke-Morais, Anna
Novaes, Hillegonda Maria Dutilh
de Sousa, Heraldo Possolo
de Carvalho, Carlos Roberto Ribeiro
Levin, Anna Sara Shafferman
Ferreira, Juliana Carvalho
Gouveia, Nelson
PLOS ONE, 2022, 17 (09):
[26] Psychiatric outcomes in patients hospitalized during the first wave of COVID-19 in Milan: A cohort study
Wiedenmann, Federico
Bergamelli, Emilio
Fior, Giulia
del Giudice, Renata
Bonazza, Federica
Battistini, Chiara Luridiana
Papa, Giuseppe Sferrazza
Lamiani, Giulia
D'Agostino, Armando
PSYCHIATRY RESEARCH, 2022, 317
[27] Use of Tocilizumab in hospitalized patients during the first wave of the COVID-19 pandemic
Javier Carrera-Hueso, Francisco
Alvarez-Arroyo, Laura
Robustillo-Villarino, Montse
Perez-Olaso, Oscar
El-Qutob, David
Martinez-Martinez, Fernando
ARS PHARMACEUTICA, 2022, 63 (02) : 166 - 172
[28] Mucormycosis in COVID-19 Patients: A Case-Control Study
Pandit, Awadh Kishor
Tangri, Poorvi
Misra, Shubham
Srivastava, Madakasira Vasantha Padma
Bhatnagar, Sushma
Thakar, Alok
Sikka, Kapil
Panda, Smriti
Vishnu, Venugopalan Y.
Singh, Rajesh Kumar
Das, Animesh
Radhakrishnan, Divya M.
Srivastava, Achal Kumar
Subramaniam, Rajeshwari
Trikha, Anjan
Agarwal, Ayush
Rajan, Roopa
Upadhyay, Vibhor
Parikipandla, Sathish
Singh, Anup
Kairo, Arvind
MICROORGANISMS, 2022, 10 (06)
[29] Predictors of death in severe COVID-19 patients at millennium COVID-19 care center in Ethiopia: a case-control study
Leulseged, Tigist Workneh
Maru, Endalkachew Hailu
Hassen, Ishmael Shemsedin
Zewde, Wuletaw Chane
Chamiso, Negat Woldehawariat
Abebe, Daniel Simeneh
Jagema, Tariku Bahiru
Banegyisa, Abdi Bekele
Gezahegn, Mesfin Abebe
Tefera, Oli Seyoum
Shiferaw, Wondmagegn Genaneh
Admasu, Teketel Tilahun
PAN AFRICAN MEDICAL JOURNAL, 2021, 38
[30] 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: A prospective cohort study
Giacomelli, Andrea
Ridolfo, Anna Lisa
Milazzo, Laura
Oreni, Letizia
Bernacchia, Dario
Siano, Matteo
Bonazzetti, Cecilia
Covizzi, Alice
Schiuma, Marco
Passerini, Matteo
Piscaglia, Marco
Coen, Massimo
Gubertini, Guido
Rizzardini, Giuliano
Cogliati, Chiara
Brambilla, Anna Maria
Colombo, Riccardo
Castelli, Antonio
Rech, Roberto
Riva, Agostino
Torre, Alessandro
Meroni, Luca
Rusconi, Stefano
Antinori, Spinello
Galli, Massimo
PHARMACOLOGICAL RESEARCH, 2020, 158

← 1 2 3 4 5 →