Predictors of Mortality among Patients Hospitalized with COVID-19 during the First Wave in India: A Multisite Case-Control Study

被引：1

作者：

Krishnan, Anand ^{[1
,36
]}

Kumar, Rakesh ^{[1
]}

Amarchand, Ritvik ^{[1
]}

Mohan, Anant ^{[2
]}

Kant, Ravi ^{[3
]}

Agarwal, Ankit ^{[4
]}

Kulshreshtha, Poorvi ^{[5
]}

Panda, Prasan Kumar ^{[6
]}

Bhadoria, Ajeet Singh ^{[7
]}

Agarwal, Neeraj ^{[8
]}

Biswas, Bijit

Nair, Rathish ^{[9
]}

Wig, Naveet ^{[10
]}

Malhotra, Rajesh ^{[11
]}

Bhatnagar, Sushma ^{[12
]}

Aggarwal, Richa ^{[13
]}

Soni, Kapil Dev ^{[13
]}

Madan, Nirupam ^{[14
]}

Trikha, Anjan ^{[15
]}

Tiwari, Pawan ^{[2
]}

Singh, Angel Rajan ^{[14
]}

Wyawahare, Mukta ^{[16
]}

Gunasekaran, Venugopalan ^{[17
]}

Sekar, Dineshbabu ^{[16
]}

Misra, Sanjeev ^{[18
]}

Bhardwaj, Pankaj ^{[19
]}

Goel, Akhil Dhanesh ^{[19
]}

Dutt, Naveen ^{[20
]}

Kumar, Deepak ^{[21
]}

Nagarkar, Nitin M. ^{[22
]}

Galhotra, Abhiruchi ^{[23
]}

Jindal, Atul ^{[24
]}

Raj, Utsav ^{[25
]}

Behera, Ajoy ^{[26
]}

Siddiqui, Sabbah ^{[27
]}

Kokane, Arun ^{[28
]}

Joshi, Rajnish ^{[29
]}

Pakhare, Abhijit ^{[28
]}

Farooque, Farhan ^{[28
]}

Pawan, Sai ^{[29
]}

Deshmukh, Pradeep ^{[30
]}

Solanki, Ranjan ^{[30
]}

Rathod, Bharatsing ^{[31
]}

Dutta, Vibha ^{[32
]}

Mohapatra, Prasanta Raghab ^{[33
]}

Panigrahi, Manoj Kumar ^{[33
]}

Barik, Sadananda ^{[34
]}

Guleria, Randeep ^{[35
]}

机构：

[1] All India Inst Med Sci AIIMS, Ctr Community Med, New Delhi, India

[2] AIIMS, Dept Pulm Crit Care & Sleep Med, New Delhi, India

[3] AIIMS, Rishikesh, India

[4] AIIMS, Dept Anaesthesia, Rishikesh, India

[5] AIIMS, Dept Physiol, Rishikesh, India

[6] AIIMS, Dept Med, Rishikesh, India

[7] AIIMS, Dept Community & Family Med, Rishikesh, India

[8] AIIMS, Dept Community & Family Med, Patna, India

[9] AIIMS, Coll Nursing, Patna, India

[10] AIIMS, Dept Med, New Delhi, India

[11] AIIMS, Jai Prakash Narayan Apex Trauma Ctr, New Delhi, India

[12] AIIMS, Dept Onco Anaesthesia, BRAIRCH, New Delhi, India

[13] AIIMS, Jai Prakash Narayan Apex Trauma Ctr, Dept Anaesthesia & Crit Care, New Delhi, India

[14] AIIMS, Dept Hosp Adm, New Delhi, India

[15] AIIMS, Dept Anaesthesiol Pain Med & Crit Care, New Delhi, India

[16] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Med, Pondicherry, India

[17] JIPMER, Dept Geriatr Med, Pondicherry, India

[18] AIIMS, Jodhpur, India

[19] AIIMS, Dept Community & Family Med, Jodhpur, India

[20] AIIMS, Dept Pulm Med, Jodhpur, India

[21] AIIMS, Dept Med, Jodhpur, India

[22] AIIMS, Raipur, India

[23] AIIMS, Dept Community & Family Med, Raipur, India

[24] AIIMS, Dept Paediat, Raipur, India

[25] AIIMS, Natl TB Eliminat Program, Raipur, India

[26] AIIMS, Dept Pulm Med, Raipur, India

[27] AIIMS, Dept Med, Raipur, India

[28] AIIMS, Dept Community & Family Med, Bhopal, India

[29] AIIMS, Dept Med, Bhopal, India

[30] AIIMS, Dept Community & Family Med, Nagpur, India

[31] AIIMS, Dept Med, Nagpur, India

[32] AIIMS, Nagpur, India

[33] AIIMS, Dept Pulm Med & Crit Care, Bhubaneswar, India

[34] AIIMS, Dept Trauma & Emergency Med, Bhubaneswar, India

[35] AIIMS, New Delhi, India

[36] All India Inst Med Sci, Ctr Community Med, Room 13,Old OT Block, New Delhi 110029, India

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2023年 / 108卷 / 04期

关键词：

ILLNESS;

D O I：

10.4269/ajtmh.22-0705

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 disease (COVID-19) has caused more than 6 million deaths globally. Understanding predictors of mortality will help in prioritizing patient care and preventive approaches. This was a multicentric, unmatched, hospital-based case-control study conducted in nine teaching hospitals in India. Cases were microbiologically confirmed COVID-19 patients who died in the hospital during the period of study and controls were microbiologically confirmed COVID-19 patients who were discharged from the same hospital after recovery. Cases were recruited sequentially from March 2020 until December-March 2021. All information regarding cases and controls was extracted retrospectively from the medical records of patients by trained physicians. Univariable and multivariable logistic regression was done to assess the association between various predictor variables and deaths due to COVID-19. A total of 2,431 patients (1,137 cases and 1,294 controls) were included in the study. The mean age of patients was 52.8 years (SD: 16.5 years), and 32.1% were females. Breathlessness was the most common symptom at the time of admission (53.2%). Increasing age (adjusted odds ratio [aOR]: 46-59 years, 3.4 [95% CI: 1.5-7.7]; 60-74 years, 4.1 [95% CI: 1.7-9.5]; and $ 75 years, 11.0 [95% CI: 4.0-30.6]); preexisting diabetes mellitus (aOR: 1.9 [95% CI: 1.2-2.9]); malignancy (aOR: 3.1 [95% CI: 1.3-7.8]); pulmonary tuberculosis (aOR: 3.3 [95% CI: 1.2-8.8]); breathlessness at the time of admission (aOR: 2.2 [95% CI: 1.4-3.5]); high quick Sequential Organ Failure Assessment score at the time of admission (aOR: 5.6 [95% CI: 2.7-11.4]); and oxygen saturation , 94% at the time of admission (aOR: 2.5 [95% CI: 1.6-3.9]) were associated with mortality due to COVID-19. These results can be used to prioritize patients who are at increased risk of death and to rationalize therapy to reduce mortality due to COVID-19.

引用

页码：727 / 733

页数：7

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