Anacardic Acid Alleviates Hypoxia/Reoxygenation-Induced Injury in Cardiomyocytes via Suppressing Nuclear Factor-Kappa B Pathway

被引：0
|
作者：
Liu, Yao [1 ]
Song, Qitai [1 ]
Tian, Ye [1 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Emergency, Luzhou 646000, Sichuan, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2023年 / 21卷 / 03期
关键词：
Anacardic acid; Ischemia-reperfusion injury; NF-kappa B pathway; CANCER CHEMOPREVENTION; APOPTOSIS; RELOCALIZATION; PROLIFERATION; CROSSTALK; SURVIVAL; KINASE; GROWTH;
D O I：
10.37290/ctnr2641-452X.21:208-214
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Anacardic acid is a natural active ingredient that possesses diverse biological and pharmacological activities, such as being an antioxidant and cardioprotective agent that inhibits histone acetylation. This study aimed to evaluate the effect of anacardic acid on myocardial ischemia-reperfusion injury. The results of our studies show a significant inhibition of apoptosis and oxidative stress in H/R-treated H9C2 cells. Our results further reveal that the cardioprotective effect of anacardic acid was dependent on the inhibition of the NF-kappa B pathway. All these data taken together show anacardic acid as a potential therapeutic target in acute myocardial infarction.
引用
收藏
页码：208 / 214
页数：7
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