Anacardic Acid Alleviates Hypoxia/Reoxygenation-Induced Injury in Cardiomyocytes via Suppressing Nuclear Factor-Kappa B Pathway

被引：0
|
作者：
Liu, Yao [1 ]
Song, Qitai [1 ]
Tian, Ye [1 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Emergency, Luzhou 646000, Sichuan, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2023年 / 21卷 / 03期
关键词：
Anacardic acid; Ischemia-reperfusion injury; NF-kappa B pathway; CANCER CHEMOPREVENTION; APOPTOSIS; RELOCALIZATION; PROLIFERATION; CROSSTALK; SURVIVAL; KINASE; GROWTH;
D O I：
10.37290/ctnr2641-452X.21:208-214
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Anacardic acid is a natural active ingredient that possesses diverse biological and pharmacological activities, such as being an antioxidant and cardioprotective agent that inhibits histone acetylation. This study aimed to evaluate the effect of anacardic acid on myocardial ischemia-reperfusion injury. The results of our studies show a significant inhibition of apoptosis and oxidative stress in H/R-treated H9C2 cells. Our results further reveal that the cardioprotective effect of anacardic acid was dependent on the inhibition of the NF-kappa B pathway. All these data taken together show anacardic acid as a potential therapeutic target in acute myocardial infarction.
引用
收藏
页码：208 / 214
页数：7
相关论文
共 50 条
  • [31] Response to "Which side is nuclear factor-kappa B on in liver injury?"
    Yoshidome, Hiroyuki
    Iida, Ayako
    Kimura, Fumio
    Shimizu, Hiroaka
    Ohtsuka, Masayuki
    Miyazaki, Masaru
    SURGERY, 2011, 149 (03) : 460 - 461
  • [32] Effects of Crocin on Nox2 Expression and ROS Level of Hypoxia/Reoxygenation-induced Injury of Cardiomyocytes
    Chao ZENG
    Yongji XING
    Lizhi BAO
    Yuanyuan WANG
    Weiqing HU
    Jun WU
    Xiaohong LIU
    Nengwu WEN
    Jiping FAN
    Medicinal Plant, 2020, (05) : 71 - 75
  • [33] Dihydroresveratrol Improves Liver Injury in Septic Rats by Regulating Nuclear Factor-Kappa B Signaling Pathway
    Hong, Jinjing
    Mao, Jinchao
    Zeng, Zhitao
    Ma, Chunlian
    Lin, Miaoyao
    Wang, Xiaodan
    CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, 2022, 20 (01) : 37 - 42
  • [34] Shock Wave Therapy Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis
    Wang, Jiannan
    Jia, Na
    Zhu, Kaiyi
    Xu, Kun
    Yan, Mingjing
    Lan, Ming
    Liu, Junmeng
    Liu, Bing
    Shen, Tao
    He, Qing
    ANALYTICAL CELLULAR PATHOLOGY, 2024, 2024
  • [35] Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide
    Kang, JL
    Lee, HW
    Lee, HS
    Pack, IS
    Chong, YH
    Castranova, V
    Koh, Y
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (12) : 2206 - 2212
  • [36] Gremlin aggravates periodontitis via activation of the nuclear factor-kappa B (NF-κB) signaling pathway
    Guan, Xiaoyue
    He, Yani
    Li, Yingxue
    Shi, Chen
    Wei, Zhichen
    Zhao, Rui
    Han, Yue
    Pan, Lifei
    Yang, Jianmin
    Hou, Tiezhou
    JOURNAL OF PERIODONTOLOGY, 2022, 93 (10) : 1589 - 1602
  • [37] Propofol inhibits hypoxia/reoxygenation-induced human gastric epithelial cell injury by suppressing the Toll-like receptor 4 pathway
    Zhang, Jiao-Li
    Fei, Su-Juan
    Qin, Xia
    Ye, Hui-Hui
    Liu, He-Xia
    Dai, Xiao-Jing
    Zhang, Yong-Mei
    KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2013, 29 (06): : 289 - 298
  • [38] Theaflavin decreases hypoxia/reoxygenation-induced inflammation and apoptosis by suppressing TLR4/NF-κB signaling in neonatal rat cardiomyocytes
    Wu, Ting
    Shen, Qin
    Wang, Tianxiao
    Sun, Jiao
    Zong, Gangjun
    Fan, Zhixing
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2020, 13 (10): : 7536 - 7543
  • [39] Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/ Prdx3 pathway ( vol 32 , pg 189 , 2024 )
    Tan, Qingyun
    Dong, Wenming
    Wang, Qingdong
    Gao, Li
    DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2025, 33 (01)
  • [40] A Soluble Receptor for Advanced Glycation End-Products Inhibits Hypoxia/Reoxygenation-Induced Apoptosis in Rat Cardiomyocytes via the Mitochondrial Pathway
    Guo, Caixia
    Zeng, Xiangjun
    Song, Juanjuan
    Zhang, Min
    Wang, Hongxia
    Xu, Xiaowei
    Du, Fenghe
    Chen, Buxing
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (09) : 11923 - 11940
12345