A creatine kinase inhibitor targeting a redox-regulated cysteine

被引：1

作者：

Chouchanl, Edward ^{[1
,2
]}

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

来源：

NATURE CHEMICAL BIOLOGY | 2023年 / 19卷 / 07期

关键词：

D O I：

10.1038/s41589-023-01274-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Creatine kinases (CKs) have emerged as a metabolic liability in many rapidly proliferating cancers. We have developed a class of covalent inhibitors that impair creatine phosphagen energetics by targeting a redox-regulated cysteine residue in the active site of CKs.

引用

页码：801 / 802

页数：2

共 50 条

[41] The NPH1 gene of Arabidopsis thaliana encodes a possibly redox-regulated serine/threonine kinase
Huala, E
Oeller, PW
Liscum, E
Briggs, WR
PLANT PHYSIOLOGY, 1997, 114 (03) : 127 - 127
[42] TIC62 redox-regulated translocon composition and dynamics
Stengel, Anna
Benz, Philipp
Balsera, Monica
Soll, Juergen
Boelter, Bettina
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (11) : 6656 - 6667
[43] Redox-Regulated Ethylene Binding to a Rhenium-Thiolate Complex
Grapperhaus, Craig A.
Ouch, Kagna
Mashuta, Mark S.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (01) : 64 - +
[44] REDISULPHID: A STRUCTURAL BIOINFORMATIC SCREEN FOR IDENTIFYING REDOX-REGULATED DISULPHIDES
Coleman, Pierre
Laddach, Anna
Fraternali, Franca
Burgoyne, Joseph R.
FREE RADICAL BIOLOGY AND MEDICINE, 2024, 218 : 28 - 28
[45] Redox-Regulated In Situ Seed-Induced Assembly of Peptides
Mo, Xiaowei
Song, Jinyan
Liu, Xin
Guo, Ruo-Chen
Hu, Binbin
Yu, Zhilin
BIOMACROMOLECULES, 2024, 25 (04) : 2497 - 2508
[46] The EGFR phosphatase RPTPγ is a redox-regulated suppressor of promigratory signaling
Joshi, Maitreyi S.
Stanoev, Angel
Huebinger, Jan
Soetje, Birga
Zorina, Veronika
Rossmannek, Lisaweta
Michel, Kirsten
Mueller, Sven A. H.
Bastiaens, Philippe I. H.
EMBO JOURNAL, 2023, 42 (10):
[47] Genome-wide analysis of redox-regulated genes in a dinoflagellate
Okamoto, OK
Hastings, JW
GENE, 2003, 321 : 73 - 81
[48] CONTROL OF ERYTHROCYTE METABOLISM BY REDOX-REGULATED TYROSINE PHOSPHATASES AND KINASES
LOW, PS
KIYATKIN, A
LI, Q
HARRISON, ML
PROTOPLASMA, 1995, 184 (1-4) : 196 - 202
[49] Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding
Winter, J.
Ilbert, M.
Graf, P. C. F.
Oezcelik, D.
Jakob, U.
CELL, 2008, 135 (04) : 691 - 701
[50] A Redox-Regulated, Heterodimeric NADH:cinnamate Reductase in Vibrio ruber
Bertsova, Yulia V.
Serebryakova, Marina V.
Anashkin, Victor A.
Baykov, Alexander A.
Bogachev, Alexander V.
BIOCHEMISTRY-MOSCOW, 2024, 89 (02) : 241 - 256

← 1 2 3 4 5 →