A creatine kinase inhibitor targeting a redox-regulated cysteine

被引：1

作者：

Chouchanl, Edward ^{[1
,2
]}

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

来源：

NATURE CHEMICAL BIOLOGY | 2023年 / 19卷 / 07期

关键词：

D O I：

10.1038/s41589-023-01274-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Creatine kinases (CKs) have emerged as a metabolic liability in many rapidly proliferating cancers. We have developed a class of covalent inhibitors that impair creatine phosphagen energetics by targeting a redox-regulated cysteine residue in the active site of CKs.

引用

页码：801 / 802

页数：2

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