A creatine kinase inhibitor targeting a redox-regulated cysteine

被引：1
|
作者：
Chouchanl, Edward [1 ,2 ]
机构：
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
来源：
NATURE CHEMICAL BIOLOGY | 2023年 / 19卷 / 07期
关键词：
D O I：
10.1038/s41589-023-01274-w
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Creatine kinases (CKs) have emerged as a metabolic liability in many rapidly proliferating cancers. We have developed a class of covalent inhibitors that impair creatine phosphagen energetics by targeting a redox-regulated cysteine residue in the active site of CKs.
引用
收藏
页码：801 / 802
页数：2
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