Visible-Light-Promoted α-Benzylation of N-Phenyl α-Amino Acids to α-Amino Phenylpropanoids

被引：6

作者：

Wang, Lin ^{[1
,2
]}

Li, Kang ^{[1
,2
]}

Ye, Tian ^{[1
,3
]}

Huang, Lei ^{[1
,3
]}

Wu, Huilan ^{[1
,2
]}

Zhang, Jingxuan ^{[1
,2
]}

Xie, Hongqi ^{[1
,3
]}

Liu, Yisong ^{[1
,3
]}

Zeng, Jianguo ^{[1
,3
]}

Cheng, Pi ^{[1
,3
]}

机构：

[1] Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Hunan, Peoples R China

[2] Hunan Agr Univ, Coll Hort, Changsha 410128, Hunan, Peoples R China

[3] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 16期

关键词：

STREPTOMYCES SP TU-6075; PROTEASOME INHIBITORS; PHOTOREDOX CATALYSIS; ARYLOMYCIN-B; AMINO-ACIDS; SANGUINARINE; DERIVATIVES; HYPOCRELLIN; DOPA; CHELERYTHRINE;

D O I：

10.1021/acs.joc.3c01196

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of & alpha;-amino phenylpropanoidsunder blue light-emitting diode irradiation has been developed through & alpha;-C-H benzylation of readily available N-phenylglycine ester with benzyl oxalates as a coupling partner under mildconditions. A range of N-phenyl glycine esters weresuccessfully converted to & alpha;-amino phenylpropanoid products inmoderate to good yields. The utility of this methodology is underlinedby its application to the late-state modification of natural products.

引用

页码：11924 / 11934

页数：11

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