Caged amino acids for visible-light photodelivery

被引：34
|
作者：
Salierno, Marcelo [1 ]
Fameli, Cecilia [1 ]
Etchenique, Roberto [1 ]
机构：
[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Inorgan Analit & Quim Fis, INQUIMAE, Buenos Aires, DF, Argentina
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2008年 / 07期
关键词：
caged compounds; phototriggers; neurophysiology;
D O I：
10.1002/ejic.200700963
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We present a photocleavable protecting group based on ruthenium bipyridyl complexes and suitable for amino acid photodelivery. We discuss the photochemical properties of the caged glutamate, which is a major neurotransmitter in the CNS. The molar absorptivity for the caged glutamate at 450 nm is epsilon = 4200 M(-1)cm(-1) and its quantum yield of photorelease at 450 mn is Phi(PD) = 0.035, which is about 17 times higher than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alpha-amino acids. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
引用
收藏
页码：1125 / 1128
页数：4
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