Caged amino acids for visible-light photodelivery

被引：34
|
作者：
Salierno, Marcelo [1 ]
Fameli, Cecilia [1 ]
Etchenique, Roberto [1 ]
机构：
[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Inorgan Analit & Quim Fis, INQUIMAE, Buenos Aires, DF, Argentina
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2008年 / 07期
关键词：
caged compounds; phototriggers; neurophysiology;
D O I：
10.1002/ejic.200700963
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We present a photocleavable protecting group based on ruthenium bipyridyl complexes and suitable for amino acid photodelivery. We discuss the photochemical properties of the caged glutamate, which is a major neurotransmitter in the CNS. The molar absorptivity for the caged glutamate at 450 nm is epsilon = 4200 M(-1)cm(-1) and its quantum yield of photorelease at 450 mn is Phi(PD) = 0.035, which is about 17 times higher than that of the most active organic caged compound at this wavelength. Similar figures are obtained for other alpha-amino acids. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
引用
收藏
页码：1125 / 1128
页数：4
相关论文
共 50 条
  • [21] VISIBLE-LIGHT CURED BIOMATERIALS
    LEE, H
    SAMPE JOURNAL, 1985, 21 (03) : 18 - 21
  • [22] PHOTOSENSITIVITY OF MITOCHONDRIA TO VISIBLE-LIGHT
    AGGARWAL, BB
    AVIDOR, Y
    PACKER, L
    FEDERATION PROCEEDINGS, 1976, 35 (07) : 1555 - 1555
  • [23] Visible-Light Photoredox Catalysis
    Xuan, Jun
    Xiao, Wen-Jing
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (28) : 6828 - 6838
  • [24] Multicolor, visible-light nanolithography
    Fourkas, John T.
    Tomova, Zuleykhan
    OPTICAL MICROLITHOGRAPHY XXVIII, 2015, 9426
  • [25] Visible-Light Photoswitching by Azobenzazoles
    Kennedy, Aaron D. W.
    Sandler, Isolde
    Andreasson, Joakim
    Ho, Junming
    Beves, Jonathon E.
    CHEMISTRY-A EUROPEAN JOURNAL, 2020, 26 (05) : 1103 - 1110
  • [26] A FOURIER SPECTROMETER FOR VISIBLE-LIGHT
    TITTEL, HO
    THIEL, E
    TRAKOWSKI, W
    SCHNEIDER, M
    HEINRICH, W
    INFRARED PHYSICS, 1984, 24 (2-3): : 323 - 328
  • [27] A Visible-Light-Sensitive Caged Serotonin
    Cabrera, Ricardo
    Filevich, Oscar
    Garcia-Acosta, Beatriz
    Athilingam, Jegath
    Bender, Kevin J.
    Poskanzer, Kira E.
    Etchenique, Roberto
    ACS CHEMICAL NEUROSCIENCE, 2017, 8 (05): : 1036 - 1042
  • [28] Visible-Light Photoredox-Catalyzed Direct Decarboxylative Functionalization of α-Keto Acids
    Sun, Huangbin
    Zhang, Qianfan
    Tang, Jie
    Chen, Xiaowen
    Jiang, Guofang
    JOURNAL OF ORGANIC CHEMISTRY, 2024, 89 (20): : 15225 - 15233
  • [29] Visible-light initiated direct oxysulfonylation of alkenes with sulfinic acids leading to β-ketosulfones
    Yang, Daoshan
    Huang, Ben
    Wei, Wei
    Li, Jin
    Lin, Gu
    Liu, Yaru
    Ding, Jiehua
    Sun, Pengfei
    Wang, Hua
    GREEN CHEMISTRY, 2016, 18 (20) : 5630 - 5634
  • [30] Decarboxylative Cyanation of Aliphatic Carboxylic Acids via Visible-Light Flavin Photocatalysis
    Ramirez, Nieves P.
    Koenig, Burkhard
    Gonzalez-Gomez, Jose C.
    ORGANIC LETTERS, 2019, 21 (05) : 1368 - 1373
12345