Visible-Light-Promoted α-Benzylation of N-Phenyl α-Amino Acids to α-Amino Phenylpropanoids

被引：6
|
作者：
Wang, Lin [1 ,2 ]
Li, Kang [1 ,2 ]
Ye, Tian [1 ,3 ]
Huang, Lei [1 ,3 ]
Wu, Huilan [1 ,2 ]
Zhang, Jingxuan [1 ,2 ]
Xie, Hongqi [1 ,3 ]
Liu, Yisong [1 ,3 ]
Zeng, Jianguo [1 ,3 ]
Cheng, Pi [1 ,3 ]
机构：
[1] Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Hunan, Peoples R China
[2] Hunan Agr Univ, Coll Hort, Changsha 410128, Hunan, Peoples R China
[3] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 16期
关键词：
STREPTOMYCES SP TU-6075; PROTEASOME INHIBITORS; PHOTOREDOX CATALYSIS; ARYLOMYCIN-B; AMINO-ACIDS; SANGUINARINE; DERIVATIVES; HYPOCRELLIN; DOPA; CHELERYTHRINE;
D O I：
10.1021/acs.joc.3c01196
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the synthesis of & alpha;-amino phenylpropanoidsunder blue light-emitting diode irradiation has been developed through & alpha;-C-H benzylation of readily available N-phenylglycine ester with benzyl oxalates as a coupling partner under mildconditions. A range of N-phenyl glycine esters weresuccessfully converted to & alpha;-amino phenylpropanoid products inmoderate to good yields. The utility of this methodology is underlinedby its application to the late-state modification of natural products.
引用
收藏
页码：11924 / 11934
页数：11
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