Analysis of Single Nucleotide Polymorphisms (SNPs) rs2234693 and rs9340799 of the ESR1 Gene and the Risk of Breast Cancer

被引：1
|
作者：
Smolarz, Beata [1 ]
Nowak, Anna Zadrozna [2 ]
Brys, Magdalena [3 ]
Forma, Ewa [3 ]
Lukasiewicz, Honorata [4 ]
Samulak, Dariusz [4 ,5 ]
Langner, Sara [6 ]
Romanowicz, Hanna [1 ]
机构：
[1] Polish Mothers Mem Hosp Res Inst, Dept Pathol, Lab Canc Genet, Lodz, Poland
[2] Med Univ Lodz, Copernicus Mem Hosp, Dept Chemotherapy, Lodz, Poland
[3] Univ Lodz, Fac Biol & Environm Protect, Dept Cytobiochem, Lodz, Poland
[4] Reg Hosp Kalisz, Dept Obstet & Gynecol & Gynecol Oncol, Kalisz, Poland
[5] President Stanislawlaw Wojciechowski Calisia Acad, Dept Obstet, Kalisz, Poland
[6] Med Univ Gdansk, Gdansk, Poland
来源：
IN VIVO | 2024年 / 38卷 / 05期
关键词：
ESR1; polymorphism; rs2234693; rs9340799; breast; ESTROGEN-RECEPTOR-ALPHA; ESR1; GENE; XBAI POLYMORPHISMS; ASSOCIATION; WOMEN; PVUII; SUSCEPTIBILITY; TARGET;
D O I：
10.21873/invivo.13676
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: The aim of this study was to analyze rs2234693 and rs9340799 polymorphisms of the ESR1 gene in the context of breast cancer risk in Polish patients. Materials and Methods: The study involved a group of 117 patients with breast cancer and 106 controls. The analyses were carried out using the polymerase chain technique. Results: The presence of the CC genotype in rs2234693 more than doubled the risk of breast cancer (p=0.04), whereas the presence of the TT genotype in rs2234693 significantly reduced the risk of developing this type of cancer (p=0.0002). The presence of the GG genotype in rs9340799 more than doubled the risk of breast cancer (p=0.04), which was confirmed by the analysis of the recessive model (p=0.04). Conclusion: The polymorphisms rs2234693 and rs9340799 of the ESR1 gene may be associated with the risk of breast cancer among Polish women.
引用
收藏
页码：2134 / 2143
页数：10
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