Analysis of Single Nucleotide Polymorphisms (SNPs) rs2234693 and rs9340799 of the ESR1 Gene and the Risk of Breast Cancer

被引：1
|
作者：
Smolarz, Beata [1 ]
Nowak, Anna Zadrozna [2 ]
Brys, Magdalena [3 ]
Forma, Ewa [3 ]
Lukasiewicz, Honorata [4 ]
Samulak, Dariusz [4 ,5 ]
Langner, Sara [6 ]
Romanowicz, Hanna [1 ]
机构：
[1] Polish Mothers Mem Hosp Res Inst, Dept Pathol, Lab Canc Genet, Lodz, Poland
[2] Med Univ Lodz, Copernicus Mem Hosp, Dept Chemotherapy, Lodz, Poland
[3] Univ Lodz, Fac Biol & Environm Protect, Dept Cytobiochem, Lodz, Poland
[4] Reg Hosp Kalisz, Dept Obstet & Gynecol & Gynecol Oncol, Kalisz, Poland
[5] President Stanislawlaw Wojciechowski Calisia Acad, Dept Obstet, Kalisz, Poland
[6] Med Univ Gdansk, Gdansk, Poland
来源：
IN VIVO | 2024年 / 38卷 / 05期
关键词：
ESR1; polymorphism; rs2234693; rs9340799; breast; ESTROGEN-RECEPTOR-ALPHA; ESR1; GENE; XBAI POLYMORPHISMS; ASSOCIATION; WOMEN; PVUII; SUSCEPTIBILITY; TARGET;
D O I：
10.21873/invivo.13676
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: The aim of this study was to analyze rs2234693 and rs9340799 polymorphisms of the ESR1 gene in the context of breast cancer risk in Polish patients. Materials and Methods: The study involved a group of 117 patients with breast cancer and 106 controls. The analyses were carried out using the polymerase chain technique. Results: The presence of the CC genotype in rs2234693 more than doubled the risk of breast cancer (p=0.04), whereas the presence of the TT genotype in rs2234693 significantly reduced the risk of developing this type of cancer (p=0.0002). The presence of the GG genotype in rs9340799 more than doubled the risk of breast cancer (p=0.04), which was confirmed by the analysis of the recessive model (p=0.04). Conclusion: The polymorphisms rs2234693 and rs9340799 of the ESR1 gene may be associated with the risk of breast cancer among Polish women.
引用
收藏
页码：2134 / 2143
页数：10
相关论文
共 50 条
  • [21] ESR1 rs9340799 Is Associated with Endometriosis-Related Infertility and In Vitro Fertilization Failure
    Paskulin, Diego Davila
    Cunha-Filho, Joao Sabino
    Paskulin, Livia Davila
    Bastos Souza, Carlos Augusto
    Ashton-Prolla, Patricia
    DISEASE MARKERS, 2013, 2013 : 907 - 913
  • [22] ESR1 polymorphism (rs2234693) influences femoral bone mass in patients with Turner syndrome
    Scalco, Renata C.
    Trarbach, Ericka B.
    Albuquerque, Edoarda V. A.
    Homma, Thais K.
    Inoue-Lima, Thais H.
    Nishi, Mirian Y.
    Mendonca, Berenice B.
    Jorge, Alexander A. L.
    ENDOCRINE CONNECTIONS, 2019, 8 (11): : 1513 - 1519
  • [23] Lack of association between the ESR1 rs9340799 polymorphism and age at menarche: a meta-analysis
    Wu, H. Y.
    Xing, X. K.
    Wang, K. J.
    Zhang, L.
    GENETICS AND MOLECULAR RESEARCH, 2016, 15 (03)
  • [24] Estrogen receptors alpha (rs2234693 and rs9340799), and beta (rs4986938 and rs1256049) genes polymorphism in prostate cancer: Evidence for association with risk and histopathological tumor characteristics in Iranian men
    Safarinejad, Mohammad Reza
    Safarinejad, Saba
    Shafiei, Nayyer
    Safarinejad, Shiva
    MOLECULAR CARCINOGENESIS, 2012, 51 : E104 - E117
  • [25] Association of ESR1 Xba1 (rs9340799) With Male Infertility: A Systematic Review and Meta-Analysis
    Qamar, Hania
    Bibi, Sadia
    Qadeer, Zeeshan
    Muzammil, Faiza
    Batool, Masooma
    Aslam, Shaista
    Akram, Ayesha
    Arshad, Adina
    Irfan, Muhammad
    AMERICAN JOURNAL OF MENS HEALTH, 2025, 19 (01)
  • [26] Association of rs 9340799 and rs 224693 SNPs in Estrogen Receptor Gene with Breast Cancer
    Ismail, Muhammad
    Khan, Jabbar
    Rauf, Zahid
    Khan, Khalid
    Rafi, Muhammad
    PAKISTAN JOURNAL OF ZOOLOGY, 2022, 54 (06) : 2977 - 2980
  • [27] ESR1 PvuII (rs2234693 T>C) polymorphism and cancer susceptibility: Evidence from 80 studies
    Liu, Xiaoqi
    Huang, Jiawen
    Lin, Huiran
    Xiong, Lingjuan
    Ma, Yunzi
    Lao, Haiyan
    JOURNAL OF CANCER, 2018, 9 (16): : 2963 - 2972
  • [28] Association between the ESR1 -351A>G single nucleotide polymorphism (rs9340799) and adolescent idiopathic scoliosis: a systematic review and meta-analysis
    Suzan Chen
    Linlu Zhao
    Darren M. Roffey
    Philippe Phan
    Eugene K. Wai
    European Spine Journal, 2014, 23 : 2586 - 2593
  • [29] Association of estrogen receptor 1 (ESR1) gene (rs2234693) polymorphism, ESR1 promoter methylation status, and serum heavy metals concentration, with breast cancer: A study on Iranian women population
    Mirzaeyan, Pardis
    Shokrzadeh, Mohammad
    Salehzadeh, Ali
    Ajamian, Farzam
    META GENE, 2020, 26
  • [30] Association of the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) Polymorphisms With Risk of Coronary Artery Disease in Iranian Patients
    Karam, Zahra Miri
    Yari, Abolfazl
    Najmadini, Atefeh
    Khorasani, Nima Norouzi
    Attari, Rezvan
    Jafarinejad-Farsangi, Saeideh
    Karam, Mohammad Ali Miri
    Najafipour, Hamid
    Saeidi, Kolsoum
    JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2024, 38 (06)
12345