Analysis of Single Nucleotide Polymorphisms (SNPs) rs2234693 and rs9340799 of the ESR1 Gene and the Risk of Breast Cancer

被引：1

作者：

Smolarz, Beata ^{[1
]}

Nowak, Anna Zadrozna ^{[2
]}

Brys, Magdalena ^{[3
]}

Forma, Ewa ^{[3
]}

Lukasiewicz, Honorata ^{[4
]}

Samulak, Dariusz ^{[4
,5
]}

Langner, Sara ^{[6
]}

Romanowicz, Hanna ^{[1
]}

机构：

[1] Polish Mothers Mem Hosp Res Inst, Dept Pathol, Lab Canc Genet, Lodz, Poland

[2] Med Univ Lodz, Copernicus Mem Hosp, Dept Chemotherapy, Lodz, Poland

[3] Univ Lodz, Fac Biol & Environm Protect, Dept Cytobiochem, Lodz, Poland

[4] Reg Hosp Kalisz, Dept Obstet & Gynecol & Gynecol Oncol, Kalisz, Poland

[5] President Stanislawlaw Wojciechowski Calisia Acad, Dept Obstet, Kalisz, Poland

[6] Med Univ Gdansk, Gdansk, Poland

来源：

IN VIVO | 2024年 / 38卷 / 05期

关键词：

ESR1; polymorphism; rs2234693; rs9340799; breast; ESTROGEN-RECEPTOR-ALPHA; ESR1; GENE; XBAI POLYMORPHISMS; ASSOCIATION; WOMEN; PVUII; SUSCEPTIBILITY; TARGET;

D O I：

10.21873/invivo.13676

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: The aim of this study was to analyze rs2234693 and rs9340799 polymorphisms of the ESR1 gene in the context of breast cancer risk in Polish patients. Materials and Methods: The study involved a group of 117 patients with breast cancer and 106 controls. The analyses were carried out using the polymerase chain technique. Results: The presence of the CC genotype in rs2234693 more than doubled the risk of breast cancer (p=0.04), whereas the presence of the TT genotype in rs2234693 significantly reduced the risk of developing this type of cancer (p=0.0002). The presence of the GG genotype in rs9340799 more than doubled the risk of breast cancer (p=0.04), which was confirmed by the analysis of the recessive model (p=0.04). Conclusion: The polymorphisms rs2234693 and rs9340799 of the ESR1 gene may be associated with the risk of breast cancer among Polish women.

引用

页码：2134 / 2143

页数：10

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