Chemical Constituents with Anti-Proliferative Activity on Pulmonary Arterial Smooth Muscle Cells from the Roots of Anthriscus sylvestris (L.) Hoffm.

被引：1
|
作者：
Liu, Yanling [1 ,2 ]
Cao, Yangang [1 ,2 ]
Zheng, Yajuan [1 ,2 ]
Niu, Ying [1 ,2 ]
Chen, Lan [1 ,2 ]
Chen, Xu [1 ,2 ]
Ma, Xinyi [1 ,2 ]
Li, Xiangda [1 ,2 ]
Zheng, Xiaoke [1 ,2 ,3 ]
Feng, Weisheng [1 ,2 ,3 ]
机构：
[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China
[2] Engn & Technol Ctr Chinese Med Dev Henan Prov Chin, Zhengzhou 450046, Peoples R China
[3] Coconstruct Collaborat Innovat Ctr Chinese Med & R, R China, Zhengzhou 450046, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 11期
关键词：
Anthriscus sylvestris; phenylpropanoid; phenol glycoside; anti-proliferative activity; COMPONENTS; GLYCOSIDES;
D O I：
10.3390/molecules29112547
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A chemical investigation of Anthriscus sylvestris roots led to the isolation and characterization of two new nitrogen-containing phenylpropanoids (1-2) and two new phenol glycosides (8-9), along with fifteen known analogues. Structure elucidation was based on HRESIMS, 1D and 2D NMR spectroscopy, and electronic circular dichroism (ECD). In addition, compounds 3, 6, 9-10, 12, and 17 exhibited inhibitory effects against the abnormal proliferation of pulmonary arterial smooth muscle cells with IC50 values ranging from 10.7 +/- 0.6 to 57.1 +/- 1.1 mu M.
引用
收藏
页数：10
相关论文
共 50 条
  • [31] Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells
    Goldsmith, Chloe D.
    Vuong, Quan V.
    Sadeqzadeh, Elham
    Stathopoulos, Costas E.
    Roach, Paul D.
    Scarlett, Christopher J.
    MOLECULES, 2015, 20 (07) : 12992 - 13004
  • [32] Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells
    Hari G. Garg
    Hicham Mrabat
    Lunyin Yu
    Charles A. Hales
    Boyangzi Li
    Casey N. Moore
    Fuming Zhang
    Robert J. Linhardt
    Glycoconjugate Journal, 2011, 28 : 419 - 426
  • [33] Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells
    Garg, Hari G.
    Mrabat, Hicham
    Yu, Lunyin
    Hales, Charles A.
    Li, Boyangzi
    Moore, Casey N.
    Zhang, Fuming
    Linhardt, Robert J.
    GLYCOCONJUGATE JOURNAL, 2011, 28 (06) : 419 - 426
  • [34] Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
    Wang, Cong
    Li, Ji-Feng
    Zhao, Lan
    Liu, Jie
    Wan, Jun
    Wang, Yue Xiu
    Wang, Jun
    Wang, Chen
    RESPIRATORY RESEARCH, 2009, 10
  • [35] Reverse remodeling and anti-proliferative effects of seralutinib in PAH precision-cut lung slices and pulmonary artery smooth muscle cells
    Schlueter, Beate Christiane
    Sitapara, Ravikumar
    Garcia, Eduardo
    Zisman, Lawrence S.
    Bruey, Jean-Marie
    Pullamsetti, Soni
    Schermuly, Ralph Theo
    Valasarajan, Chanil
    Pullamsetti, Soni Savai
    EUROPEAN RESPIRATORY JOURNAL, 2024, 64
  • [36] Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
    Cong Wang
    Ji-Feng Li
    Lan Zhao
    Jie Liu
    Jun Wan
    Yue Xiu Wang
    Jun Wang
    Chen Wang
    Respiratory Research, 10
  • [37] Mechanosensitive Channel Piezo1 in the Transition of Pulmonary Arterial Smooth Muscle Cells from a Contractile to a Proliferative Phenotype
    Chen, J.
    Rodriguez, M.
    Lai, N.
    Jain, P. P.
    Babicheva, A.
    Xiong, M.
    Li, J.
    Makino, A.
    Wang, J.
    Yuan, J. X.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (09)
  • [38] Anti-contractile and anti-proliferative responses in hum pulmonary arterial smooth muscle cells induced by ACT-333679, the active metabolite of selexipag, a non-prostanoid selective prostacyclin receptor agonist
    Gatfield, John
    Menyhart, Katalin
    Nayler, Oliver
    EUROPEAN RESPIRATORY JOURNAL, 2014, 44
  • [39] Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions
    Little, Peter J.
    Osman, Narin
    de Dios, Stephanie T.
    Cemerlang, Nelly
    Ballinger, Mandy
    Nigro, Julie
    CARDIOVASCULAR DIABETOLOGY, 2007, 6 (1)
  • [40] Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions
    Peter J Little
    Narin Osman
    Stephanie T de Dios
    Nelly Cemerlang
    Mandy Ballinger
    Julie Nigro
    Cardiovascular Diabetology, 6
12345