Chemical Constituents with Anti-Proliferative Activity on Pulmonary Arterial Smooth Muscle Cells from the Roots of Anthriscus sylvestris (L.) Hoffm.

被引：1
|
作者：
Liu, Yanling [1 ,2 ]
Cao, Yangang [1 ,2 ]
Zheng, Yajuan [1 ,2 ]
Niu, Ying [1 ,2 ]
Chen, Lan [1 ,2 ]
Chen, Xu [1 ,2 ]
Ma, Xinyi [1 ,2 ]
Li, Xiangda [1 ,2 ]
Zheng, Xiaoke [1 ,2 ,3 ]
Feng, Weisheng [1 ,2 ,3 ]
机构：
[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China
[2] Engn & Technol Ctr Chinese Med Dev Henan Prov Chin, Zhengzhou 450046, Peoples R China
[3] Coconstruct Collaborat Innovat Ctr Chinese Med & R, R China, Zhengzhou 450046, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 11期
关键词：
Anthriscus sylvestris; phenylpropanoid; phenol glycoside; anti-proliferative activity; COMPONENTS; GLYCOSIDES;
D O I：
10.3390/molecules29112547
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A chemical investigation of Anthriscus sylvestris roots led to the isolation and characterization of two new nitrogen-containing phenylpropanoids (1-2) and two new phenol glycosides (8-9), along with fifteen known analogues. Structure elucidation was based on HRESIMS, 1D and 2D NMR spectroscopy, and electronic circular dichroism (ECD). In addition, compounds 3, 6, 9-10, 12, and 17 exhibited inhibitory effects against the abnormal proliferation of pulmonary arterial smooth muscle cells with IC50 values ranging from 10.7 +/- 0.6 to 57.1 +/- 1.1 mu M.
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页数：10
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