Polyacetylenes from Saposhnikovia divaricata and their anticancer activity

被引：1
|
作者：
Sun, Yan [1 ,2 ]
Liu, Yan [1 ,2 ]
Jiang, Peng [1 ,2 ]
Wang, Si-Yi [1 ,2 ]
Pan, Juan [1 ,2 ]
Guan, Wei [1 ,2 ]
Wang, Yu-Xuan [1 ,2 ]
Kuang, Hai-Xue [1 ,2 ]
Wang, Yan-Hong [1 ,2 ,3 ]
Yang, Bing-You [1 ,2 ,3 ]
机构：
[1] Heilongjiang Univ Chinese Med, Sch Pharm, Harbin, Peoples R China
[2] Minist Educ, Key Lab Basic & Applicat Res Beiyao, Harbin, Peoples R China
[3] Heilongjiang Univ Chinese Med, Sch Pharm, Via Heping Rd 24, Harbin 150000, Heilongjiang, Peoples R China
来源：
FITOTERAPIA | 2024年 / 174卷
基金：
中国国家自然科学基金;
关键词：
Saposhnikovia divaricata; Polyacetylenes; A549; HEPG2;
D O I：
10.1016/j.fitote.2024.105876
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4+ probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhibitory effect with an IC50 value of 11.66 mu M against HEPG2.
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页数：7
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