Polyacetylenes from Saposhnikovia divaricata and their anticancer activity

被引：1

作者：

Sun, Yan ^{[1
,2
]}

Liu, Yan ^{[1
,2
]}

Jiang, Peng ^{[1
,2
]}

Wang, Si-Yi ^{[1
,2
]}

Pan, Juan ^{[1
,2
]}

Guan, Wei ^{[1
,2
]}

Wang, Yu-Xuan ^{[1
,2
]}

Kuang, Hai-Xue ^{[1
,2
]}

Wang, Yan-Hong ^{[1
,2
,3
]}

Yang, Bing-You ^{[1
,2
,3
]}

机构：

[1] Heilongjiang Univ Chinese Med, Sch Pharm, Harbin, Peoples R China

[2] Minist Educ, Key Lab Basic & Applicat Res Beiyao, Harbin, Peoples R China

[3] Heilongjiang Univ Chinese Med, Sch Pharm, Via Heping Rd 24, Harbin 150000, Heilongjiang, Peoples R China

来源：

FITOTERAPIA | 2024年 / 174卷

基金：

中国国家自然科学基金;

关键词：

Saposhnikovia divaricata; Polyacetylenes; A549; HEPG2;

D O I：

10.1016/j.fitote.2024.105876

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4+ probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhibitory effect with an IC50 value of 11.66 mu M against HEPG2.

引用

页数：7

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